Rejuran Skin Booster in Korea: Complete Guide to Salmon DNA Treatment 2025

Among Korea's many skincare innovations, Rejuran stands out as perhaps the most scientifically intriguing—and initially off-putting. A treatment using DNA extracted from salmon? The concept sounds like something from a sci-fi movie, yet this "salmon injection" has become one of Korea's most sought-after skin treatments, with global demand soaring as celebrities and dermatologists worldwide discover its remarkable regenerative effects.

Rejuran (리쥬란) isn't filler, Botox, or laser. It's a skin regeneration treatment that works at the cellular level, using polynucleotides (PN)—DNA fragments that trigger your skin's natural healing and regeneration processes. Unlike treatments that add volume or relax muscles, Rejuran fundamentally improves skin quality: boosting elasticity, reducing fine lines, refining pores, evening skin tone, and creating that coveted dewy, healthy glow Koreans call "glass skin."

Developed and manufactured in Korea, Rejuran has become a cornerstone of Korean dermatology, often called the "skin's fundamental improvement treatment." International visitors specifically travel to Seoul for Rejuran courses, attracted by both the technology's proven results and Korea's significantly lower pricing—$180-400 per session vs. $600-1,200 in Western countries. But Rejuran isn't a quick fix. It requires patience (results emerge over weeks), commitment (multiple sessions needed), and tolerance for its notorious downside: it's one of the more uncomfortable injectable treatments.

This comprehensive guide demystifies Rejuran: the science behind salmon DNA, how it differs from other skin boosters, the various types (Healer, HB, Eye), realistic pricing in Korea, what to expect from treatment and recovery, and how to determine if this unique regenerative treatment is right for your skin goals.

What is Rejuran?

The Science: Polynucleotides (PN) and PDRN

Rejuran's Active Ingredient: Rejuran contains polynucleotides (PN)—chains of nucleotides that are the building blocks of DNA. Specifically, it uses PN extracted and purified from salmon DNA, which has remarkable compatibility with human skin.

Why Salmon DNA?

• Salmon PN has molecular structure similar to human DNA
• Highly biocompatible (low rejection risk)
• Rich source of polynucleotides
• Extensive research on safety and efficacy

PN vs. PDRN: You may see both terms. Here's the difference:

• PDRN (Polydeoxyribonucleotide): Shorter DNA fragments, smaller molecular weight
• PN (Polynucleotide): Longer DNA chains, larger molecular weight, includes PDRN

Rejuran uses PN, which has larger molecules that act as "building blocks" for collagen production, offering superior moisturizing and longer-lasting effects compared to shorter PDRN chains.

How Rejuran Works

Unlike fillers (add volume) or Botox (paralyze muscles), Rejuran works through biological regeneration:

1. Cellular Activation:

• PN activates cellular growth factors
• Stimulates fibroblast activity (cells that produce collagen and elastin)
• Promotes tissue repair mechanisms

2. Collagen Production:

• Acts as raw material for new collagen synthesis
• Increases collagen density over time
• Improves skin structural integrity

3. Anti-Inflammatory:

• Reduces chronic low-grade inflammation
• Calms reactive, sensitive skin
• Helps with rosacea and redness

4. Hydration:

• PN attracts and retains moisture
• Improves skin's water-holding capacity
• Creates plump, dewy appearance

5. Antioxidant Protection:

• Protects against free radical damage
• Supports skin's natural defense mechanisms
• Slows aging process

The Result: Fundamentally healthier, more resilient skin with improved texture, elasticity, hydration, and overall quality—not just cosmetic coverage of problems, but actual improvement at the cellular level.

What Rejuran Can Do

Highly Effective For:

✅ Fine Lines and Wrinkles

• Particularly effective for crepey, etched lines
• Improves skin texture that creates wrinkle appearance
• Works from within, not just surface smoothing

✅ Skin Elasticity and Firmness

• Noticeably tighter, more resilient skin
• Improved "bounce-back"
• Lifts slightly through improved skin quality

✅ Pore Refinement

• Reduces enlarged pores
• Improves skin surface texture
• Creates smoother appearance

✅ Skin Tone and Radiance

• Evens out discoloration
• Creates luminous, healthy glow
• "Glass skin" effect

✅ Dryness and Dehydration

• Long-lasting deep hydration
• Improves skin's moisture retention
• Plumper, dewier appearance

✅ Acne Scarring (Texture)

• Improves skin quality around scars
• Smooths textural irregularities
• Combines well with other scar treatments

✅ Sensitive, Reactive Skin

• Strengthens skin barrier
• Reduces redness and reactivity
• Calms inflammation

✅ Overall Skin Quality

• Healthier, more resilient skin
• Better response to other treatments
• "Foundation" for other procedures

Moderately Effective For:

⚠️ Early-Stage Aging Prevention

• Excellent preventative treatment
• Maintains skin quality before problems arise
• Popular with Korean women in 20s-30s

⚠️ Under-Eye Concerns (with Rejuran Eye)

• Fine lines and crepiness
• Darkness from skin thickness
• Hydration and plumpness

⚠️ Rosacea and Redness

• Reduces inflammation
• Strengthens capillaries
• Not a cure, but helps manage

NOT Effective For:

❌ Deep Volume Loss

• Wrong treatment type
• Need: Fillers for volume replacement

❌ Deep Static Wrinkles

• Limited effect on deeply etched lines
• Need: Fillers, Botox, or resurfacing lasers

❌ Significant Skin Sagging

• Won't lift significantly sagging skin
• Need: Thread lift, Ultherapy, or surgery

❌ Active Acne

• Not an acne treatment (though may help skin quality)
• Need: Acne medications, lasers, or treatments

❌ Deep Acne Scars (Ice Pick, Boxcar)

• Won't fill deep indentations
• Need: Subcision, TCA CROSS, or fractional lasers

❌ Hyperpigmentation

• Not a brightening treatment
• Need: Laser toning, chemical peels, or topicals

Rejuran's Unique Position: It's not the most dramatic treatment—you won't see instant transformation. Instead, Rejuran is the "fundamental improvement" treatment that makes your skin healthier from within, creating a better canvas for other treatments and simply better skin day-to-day.

Why Rejuran Became a Global Phenomenon

Korean Innovation: Developed by Korean company Pharma Research Products (now part of Caregen), Rejuran launched in Korea in 2014 and quickly became a dermatology staple.

Scientific Validation:

• Multiple clinical studies demonstrating efficacy
• Peer-reviewed research on PN's regenerative properties
• FDA approval in various markets
• Exported to 70+ countries

Celebrity Endorsement: Korean celebrities openly discuss their Rejuran treatments, normalizing the procedure and driving global interest.

Social Media: Before/after results showing subtle but real improvement in skin quality drove viral interest, particularly the dramatic reduction in pore size and improvement in skin texture.

Professional Recognition: Dermatologists worldwide now recognize PN therapy as legitimate regenerative medicine, not just cosmetic trend.

The Korean Advantage:

• Originated in Korea
• Most experience with product
• Competitive pricing ($180-400 vs. $600-1,200 abroad)
• Advanced protocols and combination treatments

Types of Rejuran Products

The Rejuran line has expanded to address different areas and concerns. Understanding the differences helps you choose appropriately.

Rejuran Healer (Original)

The original and most popular Rejuran product.

Formulation:

• 2% PN (polynucleotide) concentration
• 2cc per syringe
• Viscous gel consistency

Best For:

• Full face treatment
• Overall skin quality improvement
• Anti-aging
• Skin regeneration
• First-time Rejuran users

Treatment Areas:

• Entire face
• Neck
• Décolletage (chest)
• Backs of hands
• Any area needing regeneration

Injection Technique:

• Multiple small injections across treatment area
• Typically 50-100+ injection points
• Creates "embossing" (raised bumps) that absorb within 24 hours

Pain Level: 6-8/10

• Considered one of the more uncomfortable injectables
• Gel is thick and causes pressure
• Many injection points = accumulated discomfort

Price in Korea: ₩250,000-400,000 ($190-310) per 2cc syringe

Duration: 6-12 months (improves with repeated treatments)

Sessions Needed: 3-4 sessions, 2-4 weeks apart

Rejuran HB (High Bioavailability)

Enhanced formulation with added hyaluronic acid and reduced pain.

Formulation:

• 2% PN (same as Healer)
• Added hyaluronic acid
• Lidocaine (local anesthetic) included
• Smoother consistency

Key Advantage: MUCH LESS PAINFUL

• 53% pain reduction vs. original Healer
• Lidocaine numbs during injection
• Smoother formula = less pressure

Best For:

• Those who want Rejuran benefits but fear pain
• Combination hydration + regeneration
• People with low pain tolerance
• Areas that are especially sensitive

Results:

• Similar regenerative effects to Healer
• Additional immediate hydration from HA
• Slightly shorter duration than Healer (some report)

Price in Korea: ₩300,000-450,000 ($230-350) per 2cc syringe

Pain Level: 3-5/10 (significantly more tolerable)

Popular in Korea: Many clinics now default to HB over Healer due to comfort

Rejuran I (Eye)

Specialized formulation for delicate eye area.

Formulation:

• Same 2% PN concentration as Healer
• Thinner, more fluid consistency
• Optimized for thin eye skin
• 1cc syringe

Best For:

• Fine lines around eyes (crow's feet)
• Under-eye hollows and crepiness
• Dark circles (from skin thinness, not pigmentation)
• Eye area elasticity and firmness

Treatment Areas:

• Crow's feet (eye corners)
• Under-eyes (tear troughs)
• Upper eyelids (rarely)
• Entire eye area

Why Separate Product?

• Eye skin is extremely thin and delicate
• Requires more precise, gentler formula
• Thinner consistency absorbs faster (less visible bumps)
• Lower risk of complications in sensitive area

Injection Technique:

• Very superficial injections
• Fewer injection points than full face
• Extremely fine needles

Pain Level: 5-6/10

• Eye area is sensitive
• But fewer injections than full face

Price in Korea: ₩200,000-350,000 ($155-270) per 1cc syringe (for both eyes)

Duration: 4-6 months

Sessions Needed: 2-3 sessions, 2-4 weeks apart

Satisfaction Rate: 95%+ (among highest of any treatment)

Rejuran S (Scar)

High-concentration formula for targeted scar treatment.

Formulation:

• Higher PN concentration than Healer
• Thicker consistency
• Designed for localized injection into scars

Best For:

• Acne scars (textural improvement)
• Surgical scars
• Injury scars
• Keloid prevention

Not Widely Available: Less common in clinics; Healer often used for scars instead.

Which Rejuran Should You Choose?

For First-Timers:

• If pain-tolerant: Healer (original, proven)
• If pain-averse: Rejuran HB (much more comfortable)

For Specific Concerns:

• Overall skin quality: Healer or HB
• Eye area only: Rejuran I (Eye)
• Acne scars: Healer (Rejuran S if available)

For Budget Travelers:

• Healer (lowest cost, most proven)

For Maximum Comfort:

• HB (worth the premium for pain reduction)

For Comprehensive Treatment:

• HB for face + Rejuran I for eyes (popular combination)

Korean Doctor Recommendations: Most now recommend HB for full-face unless budget is primary concern, as the comfort improvement significantly enhances the experience without sacrificing results.

Pricing in Korea (2025)

Per-Session Pricing

Rejuran Healer (Original) - Full Face:

• Budget clinics: ₩250,000-300,000 ($190-230) per 2cc
• Standard clinics: ₩300,000-400,000 ($230-310) per 2cc
• Premium clinics (Gangnam): ₩400,000-500,000 ($310-385) per 2cc

Rejuran HB (Reduced Pain) - Full Face:

• Standard: ₩300,000-400,000 ($230-310) per 2cc
• Premium: ₩400,000-500,000 ($310-385) per 2cc
• Gangnam high-end: ₩500,000-600,000 ($385-465) per 2cc

Rejuran I (Eye):

• Standard: ₩200,000-300,000 ($155-230) per 1cc
• Premium: ₩300,000-400,000 ($230-310) per 1cc
• Note: 1cc typically sufficient for both eyes

Package Deals (Highly Recommended)

Rejuran requires multiple sessions, so packages offer significant savings:

3-Session Packages:

Healer:

• Budget: ₩650,000-800,000 ($500-620) - saves 15-20%
• Standard: ₩800,000-1,000,000 ($620-770) - saves 20-30%

HB:

• Standard: ₩850,000-1,100,000 ($655-850) - saves 15-25%
• Premium: ₩1,100,000-1,400,000 ($850-1,080) - saves 20-30%

Rejuran I (Eye):

• 3 sessions: ₩550,000-850,000 ($425-655) - saves 15-20%

Per-session cost with package: $165-360 (vs. $190-465 single sessions)

Combination Packages

"Full Face Rejuvenation" Package:

• Rejuran HB (face) + Rejuran I (eyes)
• Price: ₩500,000-800,000 ($385-620) per session
• 3-session package: ₩1,300,000-2,000,000 ($1,000-1,540)

"Skin Booster Combo":

• Rejuran + Skin Botox (micro-botox for pores)
• Price: ₩500,000-700,000 ($385-540) per session

"Regeneration + Brightening":

• Rejuran + Laser Toning
• Price: ₩450,000-650,000 ($350-500) per session

Add-Ons Often Included

Many Korean clinics bundle extras with Rejuran:

• LED light therapy: ₩30,000-50,000 ($23-38) or free
• Soothing mask: Usually included free
• Vitamin C infusion: ₩50,000-100,000 ($38-77)

Price Comparison: Korea vs. Other Countries

Savings: 60-75% in Korea

Even with travel costs, completing a 3-session Rejuran course in Korea during a vacation is often cheaper than 1-2 sessions at home.

Factors Affecting Price

1. Clinic Location:

• Gangnam/Apgujeong: Premium (+30-50%)
• Myeongdong: Mid-range, tourist-friendly
• Hongdae/Sinchon: More affordable
• Outer Seoul: Budget options

2. Product Type:

• Healer (original): Lowest cost
• HB (pain reduction): 20-30% premium
• Eye: Premium per cc, but less needed

3. Doctor vs. Nurse:

• Nurse-administered: Standard pricing
• Doctor-administered: +20-40%
• Both are properly trained in Korea

4. Amount Used:

• 2cc (standard full face): Base price
• 3-4cc (larger area or more coverage): 1.5-2x price
• Partial face: Sometimes discounted, often not

5. Authentic Product Verification:

• Too-cheap prices (under ₩200,000/$155): Red flag for counterfeit
• Reputable clinics: Fair market pricing
• Should see sealed, authentic packaging

6. Seasonal Promotions:

• Off-peak seasons: 10-30% discounts
• First-time patient: 10-20% off
• Package deals: Best value

The Rejuran Procedure: What to Expect

Before Your Appointment

2-4 Weeks Prior:

• Stop blood thinners if possible (aspirin, fish oil, vitamin E) - consult doctor
• Avoid alcohol (increases bruising)
• Stay well-hydrated
• Continue normal skincare

1 Week Prior:

• No facial treatments (peels, lasers, microneedling)
• No waxing or harsh exfoliation
• Prepare mentally for discomfort (it's tolerable but not pleasant)

Day Before:

• No alcohol
• Hydrate well
• Get good sleep
• Take pain reliever if desired (but not blood-thinning NSAIDs)

Day of Treatment:

• Arrive with clean face (no makeup)
• Eat normal meal (don't go on empty stomach)
• Consider taking acetaminophen 30-60 min before (ask clinic)
• Bring hat/sunglasses for after

Consultation & Preparation (15-20 minutes)

Skin Assessment:

• Doctor/nurse examines your skin concerns
• Discusses realistic expectations
• Explains procedure and recovery
• Reviews medical history

Treatment Plan:

• Which Rejuran type (Healer vs HB)
• How much product needed (usually 2cc for full face)
• Number of sessions recommended (typically 3-4)
• Interval between sessions (2-4 weeks)

Pricing Confirmation:

• Clear breakdown
• Package vs. single session
• Any additional costs

Before Photos:

• Multiple angles
• Documentation for progress tracking

Face Cleansing:

• Thorough cleansing and sanitization
• Makeup removed
• Skin prepped

Numbing (20-30 minutes)

Critical for Comfort:

• Thick layer of topical numbing cream applied
• Left on for 20-30 minutes
• Covered with plastic wrap or gauze
• This waiting time is essential—don't skip or rush!

What You'll Feel:

• Tingling as cream works
• Face feels numb and heavy
• Reduced but not eliminated sensation

Note: Even with numbing, Rejuran (especially Healer) is uncomfortable. HB is significantly better due to included lidocaine.

Treatment (15-30 minutes)

Injection Process:

1. Numbing Cream Removed:

   • Face cleaned
   • Marked with injection points (sometimes)

2. Product Preparation:

   • Sealed syringe opened in front of you
   • Very fine needle attached (32-34 gauge)

3. Systematic Injection:

   • Doctor/nurse works across face methodically
   • Multiple small injections (50-100+ points)
   • Each injection creates small raised "bump" (embossing)
   • Spacing ensures even coverage

4. Injection Technique:

   • Very superficial (just under skin surface)
   • Small amount per point
   • Quick in-and-out motion
   • May feel pulling or pressure

What You'll Feel:

With Healer (Original):

• Multiple pinching sensations
• Pressure and fullness with each injection
• Accumulating discomfort as treatment continues
• Bearable but unpleasant
• Most describe it as 6-8/10 pain

With HB:

• Much more tolerable
• Lidocaine numbs from within
• Feels like pressure more than pain
• Most describe it as 3-5/10

Sensitive Areas:

• Around mouth and nose: More uncomfortable
• Forehead: Usually tolerable
• Cheeks: Moderate
• Under-eyes (Rejuran I): Quite sensitive but fewer injections

Duration:

• Full face: 15-25 minutes of actual injections
• Eye area only: 10-15 minutes
• It feels longer than it is!

Immediately After (10-15 minutes)

Your Face Will Look:

• Multiple raised white bumps ("embossing") across face
• Like bubble wrap or hives
• Pink/red from multiple injections
• Slightly swollen
• This is completely normal and expected!

Post-Treatment Care:

• Ice packs applied
• Soothing serum or cream
• LED light therapy (if included)
• Calming mask (if included)

Instructions Given:

• Aftercare sheet (request English version)
• Emergency contact info
• Next appointment scheduled

You Can:

• ✅ Leave immediately (no required waiting)
• ✅ Return to most normal activities
• ❌ Will not want to go out looking like this!

What You'll Feel:

• Tightness and fullness in face
• Throbbing or aching (mild to moderate)
• Tender to touch
• Slight burning sensation
• Relief that it's over!

Recovery & Aftercare

First 24 Hours (Critical)

The Embossing Period:

• Raised bumps (embossing) are most visible
• Gradually absorb over 12-24 hours
• Stay home if possible—you'll look puffy
• Most dissolve overnight

DO:

• ✅ Ice packs gently (10-15 min every hour)
• ✅ Sleep elevated (extra pillows)
• ✅ Drink LOTS of water (2+ liters)
• ✅ Take pain reliever if needed (acetaminophen)
• ✅ Gentle cleansing with lukewarm water
• ✅ Apply soothing, hydrating products

DON'T:

• ❌ Touch, press, or massage face
• ❌ Makeup for 24 hours minimum
• ❌ Hot water, steam, saunas
• ❌ Exercise or activities causing sweating
• ❌ Alcohol (increases swelling and inflammation)
• ❌ Sleeping face-down
• ❌ Any other facial treatments

Days 2-7

What to Expect:

• Embossing completely resolved by day 2
• Slight redness may persist 2-3 days
• Possible mild bruising (especially if many injection points)
• Skin may feel slightly dry or tight
• Minor breakout possible (purging, temporary)

DO:

• ✅ Gentle skincare routine
• ✅ Intense hydration (cream, serums, sheet masks)
• ✅ Sunscreen SPF 50+ daily
• ✅ Continue drinking lots of water
• ✅ Resume makeup after 24-48 hours (mineral preferred)

DON'T:

• ❌ Saunas, steam rooms, hot yoga (1 week)
• ❌ Swimming pools (chlorine irritates)
• ❌ Heavy exercise for 3-5 days
• ❌ Alcohol for 3-7 days
• ❌ Other facial treatments for 2 weeks
• ❌ Waxing, threading for 1 week
• ❌ Exfoliating or harsh products

Weeks 2-4

What to Expect:

• Initial results begin emerging
• Skin feels slightly smoother
• Hydration improving
• Subtle glow appearing
• Pores may look slightly refined

Skincare:

• Resume normal routine
• Continue emphasis on hydration
• Can reintroduce actives (retinol, acids) gradually
• Daily sunscreen non-negotiable

Next Session:

• Typically scheduled 2-4 weeks after first
• Ideal timing for cumulative effect

Month 1-3 (Peak Results)

What to Expect:

• Gradual, progressive improvement
• Increased firmness and elasticity
• Refined pore appearance
• More even tone
• Overall healthier-looking skin
• "Glow from within" effect

Timeline:

• Week 2-4: Subtle improvements begin
• Week 4-8: Noticeable changes
• Week 8-12: Peak results visible

Remember: Rejuran is NOT instant gratification. It's working at cellular level—regeneration takes time. Be patient!

Long-Term Maintenance

After Initial Course (3-4 sessions):

• Results last 6-12 months
• Gradual fade, not sudden disappearance
• Maintenance session every 6-12 months recommended
• Some improvements (collagen) have lasting effects

Lifestyle Factors:

• Sun protection: Essential for maintaining results
• Hydration: Drink water, use moisturizers
• Healthy lifestyle: Sleep, diet, stress management
• Avoid smoking: Destroys collagen

Safety, Side Effects & Risks

Common, Expected Effects

Normal and Temporary:

• Embossing (raised bumps): 12-24 hours
• Redness: 1-3 days
• Mild swelling: 1-2 days
• Bruising: 3-7 days (varies by individual)
• Tenderness: 2-5 days
• Mild breakout: Possible, temporary purging
• Dryness: First few days

These are NOT complications—they're expected reactions.

Uncommon Side Effects (5-10%)

More Significant Bruising:

• Some people bruise more easily
• Can last 7-14 days
• Arnica helps speed healing
• Concealer after 24 hours

Prolonged Embossing:

• Bumps lasting >48 hours (rare)
• Usually resolves on own
• Gentle massage may help (after 48 hours)

Allergic Reaction:

• Very rare (salmon PN is highly biocompatible)
• Rash, itching, prolonged redness
• Contact clinic immediately

No Results:

• Some people don't respond
• May need more sessions
• May not be right treatment for their concern

Rare Complications (Very Rare)

Infection:

• Signs: Increasing pain, severe redness, fever, pus
• Requires immediate medical treatment
• Extremely rare with proper sterile technique

Granulomas (Nodules):

• Hard lumps under skin
• Can occur weeks/months later
• Very rare with Rejuran
• May require treatment to resolve

Severe Allergic Reaction:

• Extremely rare
• Requires emergency care

Who Should NOT Get Rejuran

Absolute Contraindications:

• ❌ Allergy to PN or salmon products
• ❌ Active skin infection
• ❌ Open wounds in treatment area
• ❌ Active herpes outbreak
• ❌ Currently pregnant or breastfeeding (as precaution)
• ❌ History of severe keloid formation

Relative Contraindications (Discuss with Doctor):

• Autoimmune conditions
• Currently on immunosuppressants
• History of poor wound healing
• Very sensitive skin
• Recent other injectables (wait 2 weeks)
• Active acne breakout in area

Minimizing Risk

Choose reputable clinics:

• Licensed medical facility
• Experienced practitioners
• Proper sterile technique
• Authentic Rejuran product

Verify Product:

• Ask to see sealed packaging
• Check expiration dates
• Authentic Rejuran has holograms and security features

Communicate Clearly:

• Disclose all medications
• Mention any allergies
• Discuss previous bad reactions
• Ask all your questions

Follow Aftercare:

• Strict adherence to instructions
• No shortcuts
• Contact clinic if concerns

Finding Reputable Clinics in Korea

Red Flags to AVOID

❌ Suspiciously Low Prices:

• Under ₩200,000 ($155) for full face
• Likely counterfeit or heavily diluted product
• Authentic Rejuran has minimum cost

❌ Pressure Tactics:

• Pushing immediate purchase of 5+ sessions
• "Today only" aggressive deals
• Won't let you think it over

❌ Can't Show Product:

• Won't show sealed syringe
• Vague about product source
• No batch numbers visible

❌ Poor Hygiene:

• Unclean environment
• Questionable sterilization practices
• No proper medical setup

❌ Unrealistic Promises:

• "Instant face lift"
• "Permanent results"
• "Works for everyone 100%"

What to Look For ✅

Licensed Medical Facility:

• Registered dermatology or plastic surgery clinic
• Licensed doctor supervising
• Clean, professional environment

Authentic Product:

• Shows sealed Rejuran packaging
• Proper labeling and holograms
• Verifiable batch numbers
• Manufacturer seal intact

Experienced Staff:

• Extensive experience with Rejuran specifically
• Conservative, professional approach
• Comfortable answering technical questions
• Portfolio of before/after results

Proper Consultation:

• Thorough assessment
• Realistic expectations discussed
• Explains process thoroughly
• Provides written aftercare instructions

Good Communication:

• English support available
• Patient, not rushed
• Emergency contact provided
• Follow-up care offered

Recommended Areas in Seoul

Gangnam:

• Most experience with Rejuran
• Latest techniques
• English support
• Higher prices but quality assured

Apgujeong:

• Premium clinics
• Celebrity frequented
• Top-tier service
• Premium pricing

Sinsa/Garosu-gil:

• Good balance quality/price
• Modern facilities
• Trendy area

Myeongdong:

• Tourist-friendly
• English widely spoken
• Mid-range pricing

Booking Tips

Research:

• Google Maps reviews
• Medical tourism forums
• Korean beauty forums
• Instagram before/afters (verify authenticity)

Initial Contact:

• Email or KakaoTalk
• Ask: Rejuran types available, pricing, experience, English support

Questions to Ask:

• Is this authentic Rejuran (not generic PN product)?
• Can I see the sealed product before injection?
• What type do you recommend for me (Healer vs HB)?
• How many sessions do I need?
• What's the total cost?
• What's included in the price?
• What if I have a reaction?

First Visit:

• Consider single session before committing to package
• Evaluate: product authenticity, professionalism, comfort level, communication

Frequently Asked Questions

Q: Does Rejuran really work, or is it hype?

A: It really works, but results are subtle and gradual. Don't expect dramatic overnight transformation. Over 2-3 months and multiple sessions, you'll notice genuinely improved skin quality—firmer, smoother, more hydrated, refined pores. It's not filler-level dramatic, but it's real cellular-level improvement. Clinical studies support its efficacy.

Q: How painful is Rejuran?

A: Original Healer: 6-8/10—uncomfortable but tolerable with numbing. Rejuran HB: 3-5/10—much more comfortable. Eye area: 5-6/10 but fewer injections. It's not excruciating, but it's not pleasant. The discomfort comes from pressure of thick gel being injected at multiple points, and it accumulates. Most say it's worse than Botox, better than aggressive microneedling.

Q: Why does it cost so much less in Korea?

A: Rejuran is made in Korea, eliminating import costs. High competition among Korean clinics drives prices down. Volume-based pricing (thousands of treatments monthly) allows lower margins. In Western countries, it's still relatively new with limited supply and high demand, keeping prices elevated.

Q: Can I just do one session?

A: You can, and you'll see some improvement, but Rejuran's effects are cumulative. One session gives mild hydration and slight improvement. Three sessions provide noticeable results. Four sessions offer optimal results. Think of it like building collagen—one workout vs. a training program.

Q: How long until I see results?

A: Don't expect instant results. Timeline:

• Week 1-2: Minimal visible change
• Week 3-4: Subtle improvements (hydration, slight glow)
• Week 6-8: Noticeable changes (smoother texture, refined pores)
• Week 8-12: Peak results (firmer, more elastic skin) It's gradual, not instant gratification.

Q: How long do results last?

A: 6-12 months typically, with variation:

• First treatment: 4-6 months
• After 3-4 treatments: 8-12 months
• Some collagen improvement is semi-permanent Results fade gradually, not suddenly. Annual maintenance sessions extend benefits.

Q: Can I combine Rejuran with other treatments?

A: Yes, often recommended:

• Rejuran + Botox: Space 2 weeks apart (either order)
• Rejuran + Fillers: Space 2 weeks apart
• Rejuran + Laser toning: Same day or alternating weeks
• Rejuran + Skin Botox: Often done together
• Rejuran + Microneedling: Space 2-4 weeks Ask your practitioner about timing.

Q: Is Rejuran safe during pregnancy?

A: Avoided as precaution. No evidence of harm, but insufficient studies on pregnant women. Korean doctors typically refuse treatment during pregnancy and breastfeeding. Wait until after nursing.

Q: What's the difference between Rejuran and other "salmon injections"?

A: Rejuran is a specific brand of PN (polynucleotide) product. Other brands exist (Plinest, Nucleofill, etc.), all using similar salmon-derived PN. Rejuran has the longest track record and most research. Beware of clinics claiming "Rejuran" but using generic PN products—ask to see authentic packaging.

Q: Can I fly after Rejuran?

A: Wait at least 24 hours. The embossing (bumps) are very visible first day—you won't want to fly looking like that anyway. After 48 hours, flying is fine. Plan treatment accordingly with your travel schedule.

Q: Will Rejuran make me look puffy or unnatural?

A: No. Rejuran doesn't add volume like fillers. It improves skin quality from within. Results are natural—better skin, not "done" appearance. It's one of the most natural-looking treatments available.

Conclusion: Is Rejuran Worth It?

For those seeking fundamental skin improvement rather than quick cosmetic fixes, Rejuran offers compelling benefits—especially in Korea.

The Case for Rejuran in Korea:

Genuine Regeneration: Unlike treatments that mask problems, Rejuran actually improves skin at cellular level. You're not covering wrinkles or adding volume—you're making your skin healthier and more resilient.

Natural, Lasting Results: Results are subtle but real, natural-looking, and progressively improve. Some collagen benefits persist beyond the product's presence in skin.

Exceptional Value: At $190-385 per session in Korea ($500-1,080 for 3-session course), Rejuran costs 60-75% less than Western countries. Even with travel, doing a full course in Korea is often cheaper than 1-2 sessions at home.

Origin Advantage: Korea developed Rejuran and has most experience with it. Doctors have performed thousands of treatments, understanding nuanced techniques for different skin types and concerns.

Foundation Treatment: Rejuran improves skin quality, making other treatments (fillers, Botox, lasers) more effective. It's the "foundation" that supports other procedures.

Who Benefits Most:

✅ Ages 30-50 seeking preventative anti-aging ✅ Those with dull, dehydrated, tired-looking skin ✅ Large pores, rough texture concerns ✅ People wanting "skin health" not dramatic change ✅ Those who can afford 3-4 sessions ($500-1,500 total) ✅ Patients willing to wait for gradual results ✅ Anyone staying in Korea 6-12 weeks (can complete full course)

Who Should Reconsider:

⚠️ Very low pain tolerance (even HB has some discomfort) ⚠️ Expecting instant, dramatic results ⚠️ Budget only allows 1 session (limited benefit) ⚠️ Want volume/lift (need fillers instead) ⚠️ Leaving Korea immediately (no follow-up sessions possible)

Bottom Line:

Rejuran delivers authentic skin regeneration when approached correctly:

1. Commit to full course (3-4 sessions minimum)
2. Choose reputable clinic with authentic product
3. Accept gradual improvement timeline (2-3 months)
4. Understand it's skin quality, not dramatic transformation
5. Follow aftercare diligently (especially hydration)
6. Consider HB if pain is concern (worth the premium)

Thousands of international visitors successfully complete Rejuran courses in Korea monthly, achieving noticeably improved skin quality at accessible prices. With proper expectations—gradual regeneration, not instant miracle—Rejuran delivers on its promise of fundamentally healthier, more beautiful skin from within.

Ready to experience Rejuran? Research reputable clinics in Seoul, decide between Healer (more affordable) and HB (more comfortable), plan for 3-4 sessions spaced 2-4 weeks apart, and prepare for a journey toward genuinely better skin that glows from cellular health, not just surface treatments.

Your skin regeneration awaits!

⚠️ Medical Disclaimer: This article provides general information about Rejuran skin booster treatments in Korea. It is not intended as medical advice. Always consult with qualified, licensed medical professionals before undergoing any cosmetic procedure. Individual results vary significantly based on skin type, age, lifestyle, and many other factors. Rejuran contains DNA from salmon; those with seafood allergies should disclose this. Verify all clinic credentials and product authenticity independently. Be fully aware of potential risks and side effects. This guide does not endorse specific clinics or guarantee results. Perform thorough research before treatment.

Last Updated: October 28, 2025 Reading Time: 32 minutes