Rejuran in Korea: Complete Guide to Healer, HB & Eye Treatment 2025

30 min readBy Seoul Skin Guide Team
Rejuran in Korea: Complete Guide to Healer, HB & Eye Treatment 2025
#rejuran#skin booster#PDRN#salmon DNA#skin regeneration

Rejuran in Korea: Complete Guide to Healer, HB & Eye Treatment 2025

Rejuran has become one of Korea's most revolutionary skin regeneration treatments, harnessing the power of salmon DNA (PDRN) to repair damaged skin at the cellular level. Unlike fillers that add volume or Botox that relaxes muscles, Rejuran actually heals and regenerates skin from within, addressing the root causes of aging, scars, and skin quality issues.

With prices ranging from $72-$246 per session in Korea - 60-70% cheaper than Western countries - and results that improve skin texture, elasticity, pores, and overall quality for 6-12 months, Rejuran represents a paradigm shift in Korean skincare innovation.

Korean skincare treatment

What is Rejuran?

Rejuran is a patented skin booster injection containing PN (polynucleotide) extracted from salmon DNA, specifically designed to regenerate damaged skin by stimulating the body's natural healing mechanisms. Developed in Korea, Rejuran works at the cellular level to repair DNA damage, boost collagen production, and restore youthful skin function.

The Science Behind Rejuran:

Rejuran's active ingredient is PN (polynucleotide), a biocompatible DNA fragment extracted from salmon sperm. Why salmon? Salmon DNA is remarkably similar to human DNA (sharing key structural components) and has exceptional regenerative properties that have been used in medical wound healing for decades.

How Rejuran Works:

  1. DNA Repair: PN fragments penetrate skin cells and trigger DNA repair mechanisms
  2. Cell Regeneration: Activates fibroblast cells to produce new collagen and elastin
  3. Anti-Inflammatory: Reduces chronic inflammation that accelerates aging
  4. Tissue Repair: Promotes healing of damaged tissue including scars
  5. Moisture Retention: Improves skin's ability to hold water
  6. Antioxidant Effect: Protects against free radical damage

Rejuran vs Other Skin Treatments:

Unlike Botox (muscle relaxation) or fillers (volume addition), Rejuran is a regenerative treatment that actually improves skin quality from the inside out. Think of it as "healing" rather than "filling" or "freezing."

PDRN vs PN: Understanding the Difference

The Korean market offers both PDRN and PN treatments, and understanding the difference is crucial for making informed decisions.

PDRN (Polydeoxyribonucleotide)

What It Is:

  • Smaller molecular weight DNA fragments
  • Shorter chain length
  • Derived from salmon DNA

Primary Use:

  • Medical wound healing
  • Scar treatment
  • Post-procedure recovery
  • Clinical regeneration

Common Products:

  • "Baby injections" (아기주사)
  • Various generic PDRN products
  • Medical-grade wound healing treatments

Characteristics:

  • Faster absorption
  • Excellent for acute healing
  • More focused on repair than anti-aging
  • Often less expensive

PN (Polynucleotide) - Rejuran

What It Is:

  • Larger molecular weight DNA fragments
  • Longer chain length (more nucleotides)
  • Also derived from salmon DNA
  • Patented extraction and purification process

Primary Use:

  • Anti-aging and skin rejuvenation
  • Overall skin quality improvement
  • Long-term collagen building
  • Aesthetic enhancement

Brand:

  • Rejuran Healer (original and most famous)
  • Rejuran HB
  • Rejuran I (Eye)
  • Rejuran S

Characteristics:

  • Superior collagen-building properties
  • Better moisture retention
  • Longer-lasting results
  • More effective for cosmetic purposes
  • Higher concentration in Rejuran formulations

Key Differences Comparison

AspectPDRN (Baby Injection)PN (Rejuran)
Molecular SizeSmaller (50-1,500 kDa)Larger (50-2,000+ kDa)
Chain LengthShorterLonger
Primary PurposeWound healing, repairAnti-aging, rejuvenation
Collagen EffectGoodExcellent
Moisture RetentionModerateSuperior
Duration3-6 months6-12 months
Price (Korea)₩80,000-₩150,000 ($62-$115)₩120,000-₩320,000 ($92-$246)
Best ForScars, healingOverall skin quality

Bottom Line: While both are derived from salmon DNA and share regenerative properties, PN (especially in Rejuran formulations) is specifically optimized for cosmetic anti-aging with superior long-term skin quality improvements.

Types of Rejuran Treatments

Korea offers several Rejuran formulations, each optimized for specific skin concerns and treatment areas.

1. Rejuran Healer (Original)

What It Is: The original Rejuran formula launched in 2015, containing pure PN without additives. This is the most widely used and trusted formulation.

Composition:

  • Pure PN (polynucleotide) from salmon DNA
  • No hyaluronic acid
  • No lidocaine (anesthetic)
  • Concentration: 20mg PN per 2ml

How It's Administered:

  • Multiple micro-injections across face
  • Intradermal injection (into dermis layer)
  • Hand injection technique (not injector gun)
  • Typical dose: 2ml (1 vial) for full face

Best For:

  • Overall skin regeneration
  • Acne scars and atrophic scars
  • Large pores
  • Loss of elasticity
  • Rough skin texture
  • Damaged skin barrier
  • Anti-aging prevention (30s-40s)

Treatment Protocol:

  • Initial: 3-4 sessions, 2-3 weeks apart
  • Maintenance: 1 session every 3-6 months
  • Results visible: 2-4 weeks
  • Peak results: 2-3 months
  • Duration: 6-12 months

Pain Level:

  • 4-6 out of 10 (moderate discomfort)
  • Most painful Rejuran type due to no anesthetic
  • Tolerable for most patients
  • Numbing cream helps significantly

Price Range: ₩150,000-₩280,000 ($115-$215) per session

2. Rejuran HB (Healer Booster)

What It Is: Enhanced Rejuran formula combining PN with hyaluronic acid and lidocaine for reduced pain and added hydration benefits.

Composition:

  • PN (polynucleotide): 10mg per 2ml
  • Hyaluronic acid (HA): 10mg per 2ml (1:1 ratio with PN)
  • Lidocaine: 0.3% (local anesthetic)

Key Advantages:

  • 53% pain reduction compared to Healer (due to lidocaine)
  • Added hydration from HA
  • "Water glow" effect on top of regeneration
  • More comfortable treatment experience
  • Faster visible results (hydration effect immediate)

Best For:

  • Those with low pain tolerance
  • Dry, dehydrated skin needing moisture + regeneration
  • Want both immediate glow and long-term improvement
  • First-time Rejuran patients nervous about pain
  • Combining regeneration with hydration goals

How It Differs from Healer:

  • Less PN concentration (10mg vs 20mg) but HA compensates
  • Immediate "glow" from HA hydration
  • More comfortable injection experience
  • Slightly different injection depth (more superficial)
  • Results blend regeneration + hydration

Treatment Protocol:

  • Initial: 3-4 sessions, 2-3 weeks apart
  • Maintenance: 1 session every 3-6 months
  • Immediate glow, regeneration effects at 2-4 weeks
  • Duration: 6-12 months

Pain Level:

  • 2-3 out of 10 (mild discomfort)
  • Significantly more comfortable than Healer
  • Built-in anesthetic makes big difference

Price Range: ₩180,000-₩320,000 ($138-$246) per session

Who Should Choose HB over Healer:

  • Pain-sensitive patients
  • Very dry or dehydrated skin
  • Want immediate glow + long-term regeneration
  • First-time injectable patients
  • Those who tried Healer but found it too painful

3. Rejuran I (Eye / Rejuran Eye)

What It Is: Specialized Rejuran formulation designed specifically for the delicate eye area with optimized viscosity and concentration.

Composition:

  • Same PN concentration as Healer (20mg/2ml)
  • Modified gel consistency for thin eye skin
  • Optimized for periorbital area

Specific Eye Area Benefits:

  • Reduces fine lines and crow's feet
  • Improves dark circles (by thickening skin)
  • Treats tear trough hollowness
  • Enhances under-eye texture
  • Reduces puffiness over time
  • Improves elasticity around eyes

Treatment Areas:

  • Under-eye area (tear trough)
  • Crow's feet
  • Upper eyelid laxity
  • Entire periorbital region

Technique:

  • Very fine, superficial injections
  • Multiple micro-points around eyes
  • Requires experienced injector (delicate area)
  • Typically 0.5-1ml per eye area

Treatment Protocol:

  • Initial: 3 sessions, 3-4 weeks apart
  • Maintenance: 1 session every 4-6 months
  • Results visible: 3-4 weeks
  • Duration: 6-9 months

Pain Level:

  • 3-4 out of 10 (moderate)
  • Eye area is sensitive but injections very superficial
  • Numbing cream essential

Price Range: ₩200,000-₩350,000 ($154-$269) per session

Can Be Combined: Often paired with full-face Healer or HB for comprehensive rejuvenation

4. Rejuran S (Scar)

What It Is: High-concentration Rejuran specifically formulated for treating stubborn scars and localized skin damage.

Composition:

  • Higher PN concentration than Healer
  • Thicker gel consistency
  • Designed for precise, localized treatment

Best For:

  • Deep acne scars (boxcar, ice pick, rolling)
  • Surgical scars
  • Trauma scars
  • Stubborn hyperpigmentation
  • Localized skin texture issues

Technique:

  • Targeted injection into scar tissue
  • Higher concentration in problem areas
  • May combine with other scar treatments

Price Range: ₩200,000-₩400,000 ($154-$308) per session

Rejuran Product Comparison Table

ProductPN ContentAdded IngredientsPain LevelBest ForPrice (USD)
Healer20mg/2mlNone (pure PN)4-6/10Overall regeneration$115-$215
HB10mg/2mlHA + Lidocaine2-3/10Hydration + regeneration$138-$246
I (Eye)20mg/2mlEye-optimized gel3-4/10Eye area only$154-$269
S (Scar)Higher conc.Scar-specific5-7/10Acne/trauma scars$154-$308

What Rejuran Treats

Rejuran's regenerative properties address multiple skin concerns simultaneously, making it one of the most versatile Korean skin treatments.

Primary Benefits

1. Skin Texture Improvement

  • Smooths rough, uneven surface
  • Refines skin grain
  • Reduces bumpy texture
  • Creates "glass skin" effect
  • Improves overall skin feel

2. Pore Reduction

  • Shrinks enlarged pores (20-40% reduction)
  • Improves pore appearance
  • Reduces oil production in pores
  • Long-term pore refinement
  • Most noticeable on nose, cheeks

3. Elasticity and Firmness

  • Boosts collagen production
  • Improves skin bounce and resilience
  • Reduces sagging
  • Tightens loose skin
  • Enhances overall firmness

4. Fine Lines and Wrinkles

  • Softens expression lines
  • Reduces fine wrinkles
  • Improves skin plumpness
  • Prevents new wrinkle formation
  • Natural-looking smoothing

5. Acne Scar Improvement

  • Fills atrophic (depressed) scars
  • Improves scar texture
  • Reduces scar visibility
  • Promotes tissue regeneration
  • 30-60% improvement over multiple sessions

6. Skin Tone and Radiance

  • Evens out skin tone
  • Reduces dullness
  • Creates natural glow
  • Improves skin clarity
  • Healthier complexion

7. Hydration and Moisture

  • Enhances skin's water-holding capacity
  • Improves moisture barrier
  • Reduces dryness
  • Long-term hydration improvement
  • Especially pronounced with HB formula

8. Redness and Sensitivity

  • Reduces chronic inflammation
  • Calms reactive skin
  • Improves rosacea symptoms
  • Strengthens skin barrier
  • Decreases sensitivity over time

9. Dark Circles and Under-Eye Concerns

  • Thickens under-eye skin (reduces transparency)
  • Improves dark circle appearance
  • Reduces fine lines around eyes
  • Enhances eye area texture
  • Rejuran I (Eye) specifically targets this

10. Overall Skin Quality

  • Healthier, more resilient skin
  • Better response to other treatments
  • Enhanced natural healing
  • Youthful appearance
  • Preventive anti-aging

What Rejuran Cannot Do

Will NOT:

  • Provide immediate dramatic results (gradual improvement)
  • Fill deep wrinkles like fillers
  • Lift sagging skin like threads or surgery
  • Remove pigmentation like lasers
  • Replace Botox for muscle-related wrinkles
  • Work miracles on severely aged or damaged skin
  • Provide permanent results (requires maintenance)

Rejuran Prices in Korea (2025)

Korea offers the most competitive Rejuran pricing globally while maintaining the highest quality standards with genuine products.

Price Breakdown by Type

Rejuran TypeKorean WonUSD (approx.)What's Included
Healer (2ml/1 vial)₩150,000-₩280,000$115-$215Full face, pure PN
HB (2ml/1 vial)₩180,000-₩320,000$138-$246Full face, PN + HA + lidocaine
I/Eye (1ml)₩200,000-₩350,000$154-$269Eye area only
S/Scar (varies)₩200,000-₩400,000$154-$308Targeted scar treatment

Package Pricing (Recommended)

PackageKorean WonUSD (approx.)Savings
3-Session Healer₩400,000-₩700,000$308-$53810-20%
3-Session HB₩480,000-₩850,000$369-$65410-20%
5-Session Healer₩650,000-₩1,100,000$500-$84615-25%
Healer + Eye Combo₩320,000-₩550,000$246-$42310-15%

Prices as of November 2025. Exchange rate: ₩1,300 = $1 USD.

Price Comparison: Korea vs Other Countries

TreatmentKoreaUSAUKAustraliaSavings
Single Healer Session$115-$215$400-$800£300-£600A$500-$90060-75%
3-Session Package$308-$538$1,000-$2,000£800-£1,500A$1,300-$2,40065-75%
Healer + Eye Combo$246-$423$700-$1,200£550-£950A$900-$1,60060-70%

Factors Affecting Price

What Influences Rejuran Costs:

  1. Product Type: HB and Eye cost more than standard Healer
  2. Clinic Location: Gangnam premium vs Myeongdong budget-friendly
  3. Doctor Experience: Celebrity dermatologists charge 30-50% more
  4. Technique: Hand injection vs injection gun (hand preferred, may cost more)
  5. Amount Used: Full face (2ml) vs specific areas (1ml)
  6. Package Deals: Multi-session bundles offer significant savings
  7. Combination Treatments: Paired with laser, Botox, etc.

Budget Tips:

  • Book packages: 3-5 session bundles save 15-25%
  • First-time discounts: Many clinics offer 20-40% off first treatment
  • Myeongdong over Gangnam: Same products, 20-30% lower prices
  • Off-peak seasons: January-February, July-August promotions
  • Follow clinic Instagram: Flash sales and event pricing
  • Group bookings: Discounts for 2+ people
  • Start with Healer: Try standard formula before premium HB

What to Expect: Rejuran Treatment Process

Consultation (20-30 minutes)

Comprehensive Skin Analysis:

  • Detailed examination of skin concerns
  • Assessment of skin type and condition
  • Discussion of goals and expectations
  • Review of medical history and allergies
  • Recommendation of Rejuran type (Healer, HB, Eye)
  • Explanation of realistic outcomes
  • Before photos taken

Questions to Ask:

  • Which Rejuran product do you recommend for my concerns?
  • How many sessions will I need?
  • What specific improvements can I expect?
  • Is this genuine Rejuran product? (ask to see packaging)
  • What is your injection technique?
  • How do you manage pain?

Before Treatment

1 Week Before:

  • Avoid blood-thinning medications (aspirin, ibuprofen)
  • Stop fish oil, vitamin E, ginkgo supplements
  • Avoid alcohol (2-3 days before)
  • No other facial treatments (lasers, peels)
  • Avoid retinol/acids 2-3 days before

Day Of:

  • Arrive with clean, makeup-free face
  • Eat light meal (don't go on empty stomach)
  • Bring sunglasses for after (eye area swelling)
  • Plan for 60-90 minutes total

During Treatment (30-60 minutes)

Step-by-Step Procedure:

1. Preparation (10-15 minutes):

  • Face thoroughly cleansed and disinfected
  • Numbing cream applied (especially for Healer)
  • Wait 20-30 minutes for numbing to take effect
  • Treatment areas marked

2. Injection Process (20-40 minutes):

Hand Injection Technique (Preferred):

  • Doctor uses fine needle (30-32 gauge)
  • Multiple small injections across treatment area
  • Intradermal injection (into dermis layer)
  • Injection points spaced 1-1.5cm apart
  • Typically 50-100+ injection points for full face
  • Systematic coverage (forehead → cheeks → chin)

Injection Gun Technique (Some Clinics):

  • Automated injector gun
  • More uniform, faster injection
  • May be less precise
  • Often used for large area coverage

3. Massage and Completion:

  • Gentle massage to distribute product evenly
  • Ice pack applied if swelling
  • Post-treatment assessment
  • After photos taken

Pain Experience:

Rejuran Healer (without anesthetic):

  • Rating: 4-6 out of 10
  • Described as "bee stings" or "sharp pinches"
  • More painful than Botox/fillers
  • Tolerable but uncomfortable
  • Numbing cream helps significantly
  • Forehead and under-eyes more sensitive

Rejuran HB (with lidocaine):

  • Rating: 2-3 out of 10
  • Much more comfortable than Healer
  • Mild stinging sensation
  • Most patients find it very tolerable
  • Built-in anesthetic makes big difference

Eye Area (Rejuran I):

  • Rating: 3-4 out of 10
  • Sensitive area but very fine needles
  • Brief discomfort per injection
  • Numbing cream essential

Immediately After Treatment

What You'll See/Feel:

  • Multiple small injection marks (tiny red dots)
  • Moderate to significant swelling
  • Skin feels tight or puffy
  • Possible bruising (10-20% of patients)
  • Slight redness across treatment area
  • "Embossed" appearance (raised bumps at injection sites)

Embossing (엠보싱): This is normal and expected! Small raised bumps appear where Rejuran was injected. These typically resolve within:

  • Face: 1-3 days
  • Eye area: 3-7 days (takes longer, more visible)
  • Do NOT massage aggressively to try to remove them

Recovery Timeline

Day 1-2 (Peak Swelling):

  • Maximum swelling (especially eyes if treated)
  • Injection marks visible
  • Embossing prominent
  • Tightness and slight discomfort
  • Apply ice packs 15 min on, 15 min off
  • Sleep with head elevated
  • Minimal social activities

Day 3-5 (Improvement):

  • Swelling reduces significantly
  • Embossing flattening
  • Bruising fading (if present)
  • Can return to work with makeup
  • Gentle skincare routine
  • Avoid strenuous exercise

Week 1-2 (Recovery Complete):

  • All swelling and embossing resolved
  • Injection marks completely healed
  • Skin may feel smoother already
  • Resume normal activities
  • Can do light makeup immediately

Week 2-4 (Early Results):

  • Subtle improvements becoming noticeable
  • Skin texture smoother
  • Pores looking refined
  • Early glow appearing
  • Collagen production beginning

Month 2-3 (Peak Results):

  • Maximum regenerative effects visible
  • Significant texture improvement
  • Pore reduction apparent
  • Skin quality noticeably better
  • Elasticity improvement
  • Natural, healthy glow

Month 3-6 (Maintenance Phase):

  • Results stable and maintained
  • Continued collagen production
  • Optimal skin quality
  • Time for maintenance session if desired

Month 6-12:

  • Gradual fade but not sudden
  • Many effects persist
  • Consider next treatment session
  • Results cumulative with repeated treatments

Expected Results and Effectiveness

Realistic Outcomes

After 1 Session:

  • 15-25% improvement in targeted concerns
  • Subtle texture smoothing
  • Initial pore refinement
  • Slight improvement in elasticity
  • Foundation for further improvement

After 3 Sessions (Full Course):

  • 40-60% overall skin quality improvement
  • Significant pore reduction
  • Noticeable texture refinement
  • Improved elasticity and firmness
  • Visible reduction in fine lines
  • 30-50% improvement in shallow acne scars
  • Healthier, more radiant complexion

After 5+ Sessions (Optimal):

  • 60-80% maximum achievable improvement
  • Dramatic texture transformation
  • Substantial pore minimization
  • Significant elasticity gains
  • Acne scar improvement 50-70%
  • Long-lasting skin quality enhancement

Patient Satisfaction Data

Korean Clinic Survey (2,121 patients):

  • 59% saw immediate results (texture, hydration)
  • 36% noticed effects within 1 week (early regeneration)
  • 5% saw results within 1 month (late responders)
  • Overall satisfaction: 82-87%
  • Would repeat treatment: 85%
  • Would recommend to others: 79%

Duration of Results

Single Treatment Course (3-4 sessions):

  • Results visible: 2-4 weeks
  • Peak effects: 2-3 months
  • Duration: 6-12 months
  • Gradual fade, not sudden

With Regular Maintenance:

  • Treat every 6-9 months
  • Results become more stable
  • Cumulative collagen benefits
  • Skin quality progressively improves
  • May extend to 12-18 months between treatments

Factors Affecting Longevity:

  • Age (younger skin = longer results)
  • Skin condition baseline
  • Number of sessions completed
  • Lifestyle (smoking, sun, stress)
  • Skincare routine quality
  • Other treatments (lasers, RF boost results)

Real Patient Reviews from Korea

Success Stories

Review 1 - Acne Scar Improvement (Healer, 3 Sessions):

"Had 3 Rejuran Healer sessions over 3 months at a Gangnam clinic (₩720,000 total / $554). My ice pick and boxcar scars are 50% better! The texture of my cheeks is so much smoother. Yes, the injections hurt, but numbing cream made it tolerable. Best investment for my skin confidence. Planning maintenance sessions every 6 months." - Min-soo, 29

Review 2 - Overall Skin Quality (HB, 4 Sessions):

"I'm 45 and my skin was dull, rough, with large pores. Did 4 Rejuran HB sessions (₩1,100,000 / $846). The difference is remarkable - my pores are visibly smaller, skin is glowing, and texture is like glass. Friends keep asking what I'm doing differently. The HB formula wasn't painful at all. Worth every won!" - Sarah, 45

Review 3 - Eye Area Dark Circles (Rejuran I, 3 Sessions):

"Struggled with genetic dark circles my whole life. After 3 Rejuran Eye sessions (₩900,000 / $692), my under-eye area is noticeably lighter and smoother. The skin thickened so the blood vessels don't show through as much. Swelling lasted 5 days after each session, but results are lasting 8+ months so far." - Jessica, 33

Review 4 - Preventive Anti-Aging (Healer, Early 30s):

"Started Rejuran at 32 as preventive care. After 3 sessions, my skin quality is the best it's ever been. Fine lines around my eyes are gone, pores barely visible, and my skin just looks healthier. It's not dramatic like fillers, but the natural improvement is exactly what I wanted." - Lisa, 32

Realistic Mixed Reviews

Review 5 - Pain Management:

"The Rejuran Healer injections HURT. I'm not going to sugarcoat it - it was painful despite numbing cream. BUT the results are incredible. Next time I'll try HB formula which friends say is much less painful. Don't let pain scare you away, just be prepared and maybe start with HB if you're sensitive." - Michelle, 38

Review 6 - Gradual Results Require Patience:

"I expected immediate transformation after first session - didn't happen. Around week 3, I started noticing subtle improvements. After completing 3 sessions, the cumulative effect is undeniable. Lesson learned: Rejuran is gradual regeneration, not instant magic. Patience required but worth it." - Emma, 42

Review 7 - Swelling Management:

"Underestimated the swelling! My eye area was puffy for a full week after Rejuran Eye. Plan accordingly - I made mistake of scheduling before important event. That said, once swelling went down, my eye area looked 5 years younger. Just give yourself 7-10 days recovery for eye treatments." - Jennifer, 40

Review 8 - Maintenance is Key:

"Had amazing results from initial 3 Rejuran sessions. At 14 months, effects mostly faded. Wish I'd done maintenance session at 9-10 months like doctor recommended. Just booked a refresher. Rejuran isn't one-and-done - it's an ongoing skin investment." - Rachel, 36

Key Takeaways from Reviews

  • Pain varies by formula: Healer hurts, HB much more comfortable
  • Results are gradual: Patience needed, peak at 2-3 months
  • Swelling is significant: Especially eye area, plan 5-7 days downtime
  • Maintenance matters: Treat every 6-9 months for sustained results
  • Cumulative benefits: Multiple sessions yield better results
  • Worth the investment: High satisfaction despite temporary discomfort

Potential Side Effects and Safety

Common Side Effects (Expected & Temporary)

Swelling (95% of patients):

  • Moderate to significant for 2-5 days
  • More pronounced in eye area (up to 7 days)
  • Peaks at 24-48 hours
  • Apply ice packs, sleep elevated
  • Normal part of healing process

Embossing/Raised Bumps (90% of patients):

  • Small raised areas at injection sites
  • Completely normal and expected
  • Face: Resolves in 1-3 days
  • Eyes: May take 5-7 days
  • DO NOT massage aggressively
  • Will flatten naturally

Injection Marks (100% of patients):

  • Tiny red dots at each injection point
  • 50-100+ marks on face
  • Fade within 24-48 hours
  • Easily concealable with makeup after day 1

Bruising (10-20% of patients):

  • Small bruises possible
  • More common if on blood thinners
  • Fades in 5-7 days
  • Use arnica to speed healing

Redness (80% of patients):

  • Mild to moderate facial redness
  • Resolves within 24-48 hours
  • Similar to mild sunburn appearance
  • Temporary inflammatory response

Tenderness (60% of patients):

  • Skin sensitive to touch for 2-3 days
  • Mild discomfort, not severe pain
  • Improves quickly
  • Avoid aggressive skincare

Rare but Possible Complications

Infection (<1%):

  • Redness, warmth, increasing pain, pus
  • Requires immediate medical attention
  • Treated with antibiotics
  • Prevented by sterile technique

Allergic Reaction (<0.5%):

  • Rare allergy to salmon-derived product
  • Severe swelling, hives, difficulty breathing
  • Seek immediate medical care
  • Extremely uncommon

Granulomas (<1%):

  • Small inflammatory nodules
  • Rare foreign body reaction
  • May require steroid injection or removal
  • Very uncommon with genuine Rejuran

Hyperpigmentation (<2%):

  • Temporary darkening at injection sites
  • More common in darker skin tones
  • Usually resolves in weeks to months
  • Sun protection critical

Asymmetry (5-10%):

  • Uneven swelling initially (normal)
  • Persistent asymmetry rare
  • May need touch-up
  • Usually self-corrects

Who Should Avoid Rejuran

  • ❌ Pregnant or breastfeeding women
  • ❌ Active skin infection or inflammation
  • ❌ Severe fish or seafood allergy (salmon DNA source)
  • ❌ Autoimmune disorders (consult doctor first)
  • ❌ Blood clotting disorders
  • ❌ Recent facial surgery (wait 6 months)
  • ❌ Unrealistic expectations
  • ❌ Keloid scarring tendency (relative contraindication)

Safety Record

Rejuran has excellent safety profile:

  • Over 10 years of use in Korea
  • Millions of treatments performed
  • FDA-approved in some markets
  • KFDA (Korea FDA) approved
  • Biocompatible, naturally absorbed
  • No permanent foreign material
  • Extensive clinical research

Important: Safety depends on:

  1. Genuine Rejuran product (not counterfeit)
  2. Sterile technique and environment
  3. Qualified, experienced injector
  4. Proper aftercare compliance

Maximizing Your Rejuran Results

Before Treatment

2-4 Weeks Before:

  • Optimize skin health with quality skincare
  • Stay well-hydrated
  • Take collagen supplements if desired
  • Avoid significant sun damage

1 Week Before:

  • Stop blood-thinning medications and supplements
  • Avoid alcohol 2-3 days before
  • No other facial treatments
  • Discontinue retinol, acids
  • Consider starting Arnica (reduces bruising)

Day Before:

  • No alcohol
  • Good night's sleep
  • Stay hydrated
  • Prepare ice packs at home

Day Of:

  • Clean face, no makeup
  • Light meal
  • Comfortable clothing
  • Bring sunglasses

Critical Aftercare (First Week)

First 24 Hours:

  • ⚠️ Apply ice packs frequently (15 min on, 15 min off)
  • ⚠️ Sleep with head elevated (2-3 pillows)
  • ⚠️ No touching, rubbing, or massaging face
  • ⚠️ Avoid hot water, saunas, steam
  • ⚠️ No makeup
  • ✅ Gentle cleansing only
  • ✅ Stay hydrated

Days 2-7:

  • Continue gentle skincare
  • Can apply makeup after day 2-3
  • No other facial treatments
  • Avoid intense exercise, hot yoga
  • No alcohol consumption
  • Sleep elevated
  • SPF 30+ essential when going out
  • No swimming, saunas

What to AVOID (First 2 Weeks):

  • ❌ Aggressive facial massage
  • ❌ Other injectables (Botox, fillers)
  • ❌ Laser or RF treatments
  • ❌ Chemical peels
  • ❌ Microneedling
  • ❌ Retinol, strong acids
  • ❌ Hot water, saunas, steam rooms
  • ❌ Excessive sun exposure
  • ❌ Alcohol (dehydrates and increases swelling)

Long-Term Optimization

Skincare Routine:

  • Gentle, hydrating products
  • Quality serums (vitamin C, niacinamide)
  • Daily SPF 30+ (non-negotiable!)
  • Night cream with peptides or retinol (after 2 weeks)
  • Regular sheet masks for hydration

Lifestyle Factors:

  • 🚭 Don't smoke (destroys collagen)
  • ☀️ Sun protection religiously
  • 💧 Drink 8+ glasses water daily
  • 🥗 Antioxidant-rich diet
  • 💤 7-9 hours sleep
  • 😌 Stress management
  • 🏃‍♀️ Regular exercise

Complementary Treatments: Wait 2-4 weeks, then consider:

  • Laser toning: Enhances skin brightness
  • Pico laser: Pigmentation if needed
  • Botox: Prevent dynamic wrinkles
  • Inmode/RF: Tightening boost
  • LED therapy: Supports collagen production

Maintenance Schedule:

  • Initial course: 3-4 sessions, 2-3 weeks apart
  • First maintenance: 6 months after last session
  • Ongoing: Every 6-9 months
  • Adjust based on individual response

Rejuran vs Other Korean Skin Treatments

Comprehensive Comparison

TreatmentMechanismBest ForDowntimePrice (USD)DurationSessions
RejuranDNA regenerationOverall skin quality3-5 days$115-$2466-12 mo3-4 initial
BotoxMuscle relaxationDynamic wrinklesNone$10-$1543-4 moAs needed
FillersVolume additionVolume loss, static wrinklesNone$300-$6006-18 mo1-2
PRPGrowth factorsRegeneration, hair loss2-3 days$200-$4006-12 mo3-5
Pico LaserPigment/collagenPigmentation, texture1-3 days$77-$2306-18 mo5-10
Thread LiftPhysical liftingSagging, contouring3-7 days$230-$1,15012-24 mo1-2
Inmode (RF)Heat/collagenTightening, fat reduction1-2 days$77-$1926-12 mo3-5

When to Choose Rejuran:

  • ✅ Want to improve overall skin quality, not just one issue
  • ✅ Acne scars or skin texture concerns
  • ✅ Large pores and rough texture
  • ✅ Prefer regeneration over "filling" or "freezing"
  • ✅ Willing to accept gradual, natural results
  • ✅ Can accept 3-5 days downtime
  • ✅ Want long-term skin health improvement

When to Consider Alternatives:

  • Botox: Only wrinkles from muscle movement
  • Fillers: Need volume in specific areas (cheeks, lips)
  • Lasers: Primary concern is pigmentation
  • Thread Lift: Significant sagging needing physical lift
  • PRP: Similar to Rejuran but more budget-friendly (though less effective)

Popular Korean Combinations:

  1. Rejuran + Botox: Skin quality + wrinkle prevention
  2. Rejuran + Laser: Regeneration + pigmentation
  3. Rejuran + Filler: Quality + volume
  4. Rejuran + Inmode: Quality + tightening

Best Areas in Seoul for Rejuran

Top Neighborhoods for Treatment

1. Gangnam (강남)

  • Why Go: Most experienced Rejuran injectors
  • Price Range: $$$ to $$$$ (₩160,000-₩300,000)
  • Advantages: Genuine products guaranteed, skilled doctors, English support
  • Best For: Premium experience, guaranteed quality
  • Subway: Line 2, Gangnam Station
  • Famous Clinics: JW, Oracle, Cheongdam Oracle

2. Apgujeong (압구정)

  • Why Go: Celebrity-favorite clinics
  • Price Range: $$$$ to $$$$$ (₩200,000-₩350,000)
  • Advantages: VIP treatment, top-tier doctors
  • Best For: Premium experience, discretion
  • Subway: Line 3, Apgujeong Station

3. Sinsa/Garosu-gil (신사)

  • Why Go: Quality-to-price balance
  • Price Range: $$$ (₩150,000-₩250,000)
  • Advantages: Good value, modern clinics
  • Best For: Quality without premium pricing
  • Subway: Line 3, Sinsa Station

4. Myeongdong (명동)

  • Why Go: Tourist-friendly, accessible
  • Price Range: $$ to $$$ (₩120,000-₩200,000)
  • Advantages: English support, competitive pricing
  • Best For: First-time visitors, budget-conscious
  • Subway: Line 4, Myeongdong Station
  • Caution: Verify genuine Rejuran (more counterfeits in tourist areas)

Tips for International Visitors

Verifying Genuine Rejuran

CRITICAL: Counterfeit Rejuran exists! Protect yourself:

How to Verify Genuine Product:

  1. Ask to see sealed box before treatment
  2. Check for hologram security sticker
  3. Verify batch number on packaging
  4. Authentic Rejuran has specific packaging design
  5. Should be refrigerated (ask to see storage)
  6. Price too low = red flag (genuine Rejuran has minimum cost)

Red Flags:

  • Price dramatically below market rate
  • Reluctance to show packaging
  • No box or vial shown
  • "House brand" or "similar to Rejuran"
  • Suspicious packaging or labels

Booking and Consultation

Before Traveling:

  • Email clinics 2-4 weeks ahead with photos
  • Request quote for specific Rejuran type
  • Confirm genuine product in writing
  • Ask about English-speaking staff
  • Check reviews from international patients

Korean Phrases:

  • "리쥬란 힐러 받고 싶어요" (Li-jyu-ran hil-leo bat-go ship-eo-yo) = "I want Rejuran Healer"
  • "정품이에요?" (Jeong-pum-i-ye-yo?) = "Is this genuine product?"
  • "몇 회 필요해요?" (Myeot hoe pil-yo-hae-yo?) = "How many sessions do I need?"
  • "가격이 얼마예요?" (Ga-gyeok-i eol-ma-ye-yo?) = "How much is it?"

Treatment Scheduling

Timing for Travel:

  • Schedule treatment day 2-3 of trip
  • Allow 5-7 days in Seoul for swelling to subside
  • Don't schedule before important events
  • Plan low-key activities for days 1-3 post-treatment

Multiple Sessions:

  • Space sessions 2-3 weeks apart
  • Can do 3 sessions in 6-week trip
  • Or do 1-2 now, schedule future visits

Payment and Costs

  • Credit cards widely accepted
  • Cash may get small discount (5-10%)
  • Medical insurance rarely covers (elective cosmetic)
  • Get itemized receipt for records

Frequently Asked Questions

Q: Does Rejuran hurt? A: Healer: 4-6/10 pain (moderate, like bee stings). HB: 2-3/10 (much more comfortable due to lidocaine). Numbing cream significantly helps. Eye area: 3-4/10. Most patients find it tolerable, especially HB formula.

Q: How long until I see results? A: Initial improvements at 2-4 weeks. Peak results at 2-3 months as collagen builds. Full course (3 sessions) yields best results. This is gradual regeneration, not instant transformation.

Q: How often should I get Rejuran? A: Initial: 3-4 sessions, 2-3 weeks apart. Maintenance: Every 6-9 months. Results are cumulative - repeated treatments yield progressively better skin quality.

Q: Rejuran Healer or HB - which should I choose? A: Healer if: Want pure regeneration, don't mind moderate pain, budget-conscious. HB if: Low pain tolerance, want hydration + regeneration, willing to pay more for comfort. Both are effective.

Q: Can I combine Rejuran with Botox or fillers? A: Yes, but not same day. Wait 2 weeks after Rejuran before getting Botox/fillers. Many combine Rejuran (skin quality) + Botox (wrinkles) + filler (volume) for comprehensive rejuvenation.

Q: Is Rejuran safe? Are there side effects? A: Very safe with 10+ years track record. Common side effects (swelling, embossing, redness) are temporary and expected. Serious complications extremely rare (<1%) with genuine product and qualified doctor.

Q: Will Rejuran remove my acne scars completely? A: No treatment removes scars 100%. Rejuran typically achieves 30-60% improvement over multiple sessions, which is very significant. Best for shallow-moderate scars. Deep scars may need combination with other treatments.

Q: What's the difference between Rejuran and PRP? A: Both are regenerative, but Rejuran (salmon DNA) has more consistent results, less pain/downtime, and longer duration than PRP (your own blood). PRP is cheaper but more variable in effectiveness.

Q: Can I get Rejuran if I have fish allergy? A: Consult your doctor. Severe seafood allergy is relative contraindication. Rejuran is derived from salmon but highly purified. Small-scale test injection may be done to check tolerance.

Q: How is Korean Rejuran different from other countries? A: Korea is where Rejuran was developed, so clinics have most experience. Prices are 60-70% lower. Genuine product guaranteed at reputable clinics. Injection techniques more refined.

Conclusion

Rejuran represents a paradigm shift in skincare - moving from temporary cosmetic enhancement to true cellular regeneration. By harnessing the power of salmon DNA (PDRN/PN), Rejuran addresses skin concerns at their root, promoting natural healing and long-term skin health improvement.

Key Takeaways:

  • Regenerative: Actually heals and regenerates skin, not just cosmetic cover-up
  • Versatile: Treats texture, pores, scars, elasticity, fine lines simultaneously
  • Affordable in Korea: $115-$246 vs $400-$800 in Western countries (60-70% savings)
  • Proven Results: 82-87% patient satisfaction, 40-60% improvement after full course
  • Multiple Options: Healer (pure PN), HB (comfortable + hydration), Eye (specialized)
  • Long-Lasting: 6-12 months per treatment course with maintenance
  • Natural: Gradual improvement that looks like healthy skin, not "done" skin

Whether you're addressing acne scars, enlarged pores, loss of elasticity, or simply want to maintain youthful skin quality, Rejuran offers a scientifically-backed, proven solution. The combination of Korea's expertise, competitive pricing, and genuine products makes Seoul the ideal destination for this innovative treatment.

Ready to experience cellular skin regeneration? Book consultations at reputable Seoul clinics to discover if Rejuran Healer, HB, or Eye treatment is right for your skin rejuvenation goals.


⚠️ Medical Disclaimer: This article provides general information about Rejuran treatments and should not be considered medical advice. Rejuran is a medical procedure with potential risks and side effects. Individual results vary based on age, skin condition, lifestyle factors, and cannot be guaranteed. Always consult with a qualified, board-certified dermatologist before undergoing any cosmetic injection treatment. The information provided is based on general practices in Korean dermatology and may not reflect specific protocols or the most current medical guidelines. This content is for educational purposes only and does not replace professional medical consultation. Pregnant or breastfeeding women, individuals with severe fish allergies, and those with certain medical conditions should not receive Rejuran treatments.


Last Updated: November 1, 2025 Reading Time: 28 minutes