Rejuran in Korea: Complete Guide to Salmon DNA Treatment 2025

Rejuran has become one of the most sought-after skin treatments in Korea, often called "salmon injection" for its unique ingredient: polynucleotides (PN) extracted from salmon DNA. This revolutionary skin booster promises to turn back the clock on aging skin through biological regeneration rather than simply filling wrinkles.

If you're considering Rejuran treatment during your visit to Korea, this comprehensive guide covers everything you need to know—from the science behind PDRN to pricing, treatment types, and the best clinics in Seoul.

What is Rejuran? Understanding PDRN (Salmon DNA)

Rejuran is a skin booster treatment that injects polynucleotides (PN), also known as PDRN (polydeoxyribonucleotide), directly into the dermis layer of your skin. These polynucleotides are biocompatible molecules extracted from salmon DNA that closely match human DNA structure.

How PDRN Works

Unlike dermal fillers that simply add volume or Botox that relaxes muscles, Rejuran works at a cellular level to:

• Activate skin regeneration: PDRN stimulates fibroblast activity, the cells responsible for producing collagen and elastin
• Improve skin environment: Enhances blood circulation and promotes healthy tissue growth
• Reduce inflammation: Has anti-inflammatory properties that help calm irritated skin
• Repair damaged tissue: Helps restore the skin's natural structure and thickness

The key difference from other treatments is that Rejuran doesn't just mask aging signs—it actually helps your skin heal and regenerate itself from within.

Why Salmon DNA?

Salmon DNA is used because it has exceptional biocompatibility with human skin and contains small molecular structures that can penetrate deep into the dermis. The polynucleotides extracted from salmon are highly purified and safe for injection into human skin.

Types of Rejuran: Which One is Right for You?

Rejuran comes in several formulations, each designed for specific concerns and treatment areas. Understanding the differences will help you choose the right option for your needs.

1. Rejuran Healer (Original)

The Original Formula

Rejuran Healer is the flagship product and most commonly used version. It contains pure PN without any additives.

Best for:

• Overall skin regeneration
• Fine lines and wrinkles
• Skin texture improvement
• Loss of elasticity
• Those prioritizing maximum regeneration effects

Characteristics:

• Volume: 2ml × 2 syringes per treatment
• Pure PN formulation
• Stronger regenerative effect
• More noticeable pain during injection (no anesthetic)
• May cause temporary embossing effect (bumpy texture immediately after injection)

2. Rejuran HB Plus

The Enhanced Formula

HB Plus is an upgraded version that combines PN with hyaluronic acid (HA) and lidocaine (anesthetic).

Best for:

• Those seeking both regeneration and instant hydration
• Pain-sensitive patients
• Wanting the "water glow" effect
• Comprehensive anti-aging treatment

Characteristics:

• Contains PN + Hyaluronic Acid + Lidocaine
• 53% less pain than original Rejuran Healer (according to manufacturer)
• Immediate hydration and glow
• Smoother injection experience
• Combines regeneration with moisture boost

Key Differences from Healer:

• Less pain during treatment
• Adds instant plumping and hydration
• Slightly less concentrated PN than Healer
• Higher price point

3. Rejuran I (Eye)

Eye Area Specialist

A specialized formulation designed specifically for the delicate eye area with lower viscosity.

Best for:

• Under-eye fine lines
• Dark circles
• Thin, crepey eyelid skin
• Eye area elasticity loss

Characteristics:

• Volume: 1ml × 1 syringe
• Lower viscosity for delicate skin
• Pure PN formulation
• Targeted application around eyes

4. Rejuran S (Scar)

Scar Treatment Formula

High-concentration PN specifically designed for treating scars, particularly acne scars and enlarged pores.

Best for:

• Atrophic acne scars
• Ice pick and boxcar scars
• Large pores
• Localized skin texture issues

Characteristics:

• Volume: 1ml × 1 syringe
• Higher PN concentration
• Targeted injection into scar tissue
• Often combined with other treatments like microneedling or laser

Benefits of Rejuran Treatment

Rejuran offers a wide range of skin benefits that develop progressively over weeks and months:

Immediate Benefits (1-2 weeks)

• Improved skin hydration
• Reduced redness and irritation
• Calmer, more balanced skin
• Smoother texture

Progressive Benefits (4-12 weeks)

• Wrinkle reduction: Fine lines and shallow wrinkles become less visible
• Enhanced elasticity: Skin feels firmer and more resilient
• Thicker dermis: Actual structural improvement in skin thickness
• Better tone: More even skin color and reduced dullness
• Pore refinement: Smaller-looking pores due to improved skin structure
• Scar improvement: Gradual softening of acne scars and texture issues

Long-term Benefits (3-6 months)

• Sustained collagen production
• Overall skin quality improvement
• Better response to other treatments
• Preventative anti-aging effects

Rejuran Prices in Korea (2025)

One of the main advantages of getting Rejuran in Korea is the significantly lower cost compared to Western countries. Here are current price ranges:

Standard Pricing in Seoul

*Exchange rate: ₩1,300 = $1 USD

Package Deals

Most clinics offer package pricing for multiple sessions, which is recommended since Rejuran works best with a series of treatments:

First-Timer Promotions

Many Gangnam clinics offer special rates for first-time international patients:

• Rejuran Healer: ₩108,900-163,900 (approximately $84-126)
• Often includes free consultation and aftercare products

Korea vs. International Price Comparison

Key Insight: Getting Rejuran in Korea can save you 70-85% compared to Western countries, even accounting for travel costs. A package of 3 sessions in Korea costs less than a single session in most Western cities.

The Treatment Process: What to Expect

Understanding the treatment process helps reduce anxiety and ensures you're prepared for your appointment.

Before Treatment (1-2 weeks prior)

Consultation:

• Most clinics offer free consultations
• Doctor will assess your skin condition
• Discuss treatment goals and expectations
• Review medical history and allergies
• Determine which Rejuran type is best for you

Pre-treatment Instructions:

• Avoid blood-thinning medications (aspirin, ibuprofen) for 3-7 days
• Stop using retinoids and strong acids 2-3 days before
• Avoid alcohol 24 hours before treatment
• Arrive with clean, makeup-free skin

During Treatment (30-45 minutes)

Step-by-Step Process:

1. Cleansing (5 minutes)

   • Thorough cleansing to remove all makeup and impurities
   • Disinfection of treatment area

2. Numbing (15-20 minutes)

   • Topical anesthetic cream applied (especially for Healer version)
   • Wait time for numbing to take effect
   • HB Plus contains lidocaine so may require less pre-numbing

3. Injection (10-15 minutes)

   • Multiple small injections across treatment area
   • Typically 50-100 injection points for full face
   • Pattern depends on skin concerns
   • Healer: More noticeable pinching sensation
   • HB Plus: Significantly less painful

4. Post-treatment Care (5 minutes)

   • Gentle cooling to reduce redness
   • Application of soothing serum
   • Sun protection
   • Aftercare instructions

Immediately After Treatment

You'll notice:

• Embossing effect: Small bumps where injections were made (especially with Healer)
• Redness and slight swelling
• Possible minor bruising at injection sites
• Mild tenderness

These effects are normal and typically resolve within 24-48 hours.

Results Timeline: When Will You See Changes?

Rejuran is not an instant gratification treatment—it works progressively as your skin regenerates. Here's what to expect:

Week 1: Initial Healing

• Embossing disappears (usually within 24 hours)
• Redness and swelling subside
• Skin may feel slightly tighter
• Subtle improvement in hydration

Weeks 2-3: Early Changes

• Skin texture becomes smoother
• Improved radiance and glow
• Less visible redness or irritation
• Better makeup application

Weeks 4-6: Visible Improvements

• Fine lines start to soften
• Skin feels noticeably firmer
• Better elasticity when you touch your face
• More even tone
• Pores appear smaller

Weeks 8-12: Peak Results

• Maximum wrinkle reduction
• Significant improvement in skin thickness
• Enhanced overall skin quality
• Sustained hydration and glow
• Cumulative effects from multiple sessions become apparent

Maintenance Phase (3-6 months)

• Effects gradually fade but don't disappear completely
• Skin remains better than pre-treatment baseline
• Maintenance sessions recommended every 3-6 months

Important: Results vary by individual. Factors affecting outcomes include:

• Age and baseline skin condition
• Lifestyle factors (sun exposure, smoking, diet)
• Number of treatment sessions
• Consistency with aftercare
• Overall health and skin care routine

Side Effects and What to Watch For

Rejuran is considered a safe treatment with minimal side effects, but it's important to know what's normal and what isn't.

Common and Expected

These are normal reactions that don't require medical attention:

Embossing Effect (Bumpy Texture)

• Small raised bumps at injection sites
• NOT a side effect—indicates proper dermal injection
• Resolves within 24-48 hours
• More pronounced with Healer, less with HB Plus

Redness and Swelling

• Mild to moderate redness across treatment area
• Usually resolves within a few hours to 1 day
• Manage with cold compresses

Bruising

• Small bruises at injection points
• More common in those with thin skin or taking blood thinners
• Typically fades within 3-7 days
• Can be covered with makeup after 24 hours

Tenderness

• Mild pain or sensitivity when touching treated area
• Usually resolves within 2-3 days
• Normal as skin is healing

Itching

• Mild itching as skin heals
• Manage with frequent application of moisturizer
• Avoid scratching

Rare but Possible

Contact your clinic if you experience:

• Severe swelling lasting more than 3 days
• Intense pain not relieved by over-the-counter medication
• Signs of infection: Increased warmth, pus, worsening redness
• Allergic reaction: Severe itching, hives, difficulty breathing (extremely rare)
• Nodules or lumps that don't resolve within a week

Who Should Avoid Rejuran

• Pregnant or breastfeeding women
• Those with seafood or salmon allergies (controversial—consult doctor)
• Active skin infections or inflammation
• Autoimmune disorders (consult doctor first)
• Bleeding disorders
• Keloid scarring tendency

Aftercare: Maximizing Your Results

Proper aftercare is crucial for optimal results and preventing complications.

First 24 Hours (Critical Period)

DO:

• Keep treatment area clean and dry
• Apply cold compress for 15 minutes every hour to reduce swelling
• Sleep with head elevated to minimize swelling
• Drink plenty of water
• Use only gentle, prescribed products

DON'T:

• Touch or massage the treatment area
• Apply makeup (wait at least 6-24 hours)
• Wash your face (wait minimum 6 hours, preferably 24)
• Exercise or engage in strenuous activity
• Expose skin to heat (hot showers, saunas, direct sun)
• Consume alcohol

Days 2-7 (Healing Phase)

Skincare Routine:

• Resume gentle cleansing with lukewarm water
• Use mild, fragrance-free cleanser
• Pat (don't rub) skin dry
• Apply hydrating, soothing products
• Use broad-spectrum SPF 50+ sunscreen daily
• Avoid active ingredients (retinol, AHA, BHA, vitamin C)

Activities to Avoid:

• Swimming pools (chlorine)
• Saunas and steam rooms
• Hot yoga or intense exercise
• Facial massage or spa treatments
• Excessive sun exposure
• Drinking alcohol
• Smoking (impairs healing)

Week 2 Onward (Recovery Phase)

• Gradually reintroduce active skincare ingredients
• Maintain excellent sun protection
• Keep skin well-hydrated
• Consider gentle facial massage to improve circulation
• Schedule follow-up treatments as recommended (typically 2-4 weeks apart)

Long-term Maintenance

To maximize and prolong your Rejuran results:

• Sun protection: Daily SPF is non-negotiable
• Hydration: Drink adequate water and use hydrating products
• Healthy lifestyle: Balanced diet, adequate sleep, no smoking
• Gentle skincare: Avoid harsh treatments between sessions
• Regular maintenance: Schedule touch-up sessions every 3-6 months

Frequently Asked Questions

How painful is Rejuran treatment?

Rejuran Healer: Moderate pain. Most patients describe it as tolerable but uncomfortable, with a pinching or stinging sensation. Topical numbing cream helps significantly.

Rejuran HB Plus: Minimal pain. The lidocaine in the formula reduces discomfort by about 50-53%. Most patients find it quite tolerable.

Pain level: 4-6/10 for Healer, 2-4/10 for HB Plus (varies by individual pain tolerance)

How many sessions do I need?

Standard protocol: 3-4 sessions spaced 2-4 weeks apart for optimal results.

Why multiple sessions?: Rejuran works by triggering your body's natural regeneration. Results are cumulative—each session builds on the previous one.

Maintenance: After the initial series, maintenance sessions every 3-6 months help sustain results.

How long do Rejuran results last?

• Peak effects: 2-3 months after completing initial series
• Visible results: 6-12 months
• Baseline improvement: Skin remains better than pre-treatment even after effects fade
• With maintenance: Results can be sustained indefinitely

Can I combine Rejuran with other treatments?

Yes, Rejuran works well with:

• Botox: Different mechanisms; often combined in same session
• Fillers: Can be done together; Rejuran improves skin quality around filler
• Lasers: Usually spaced 2-4 weeks apart
• Microneedling: Sometimes combined for enhanced results
• Chemical peels: Space at least 2 weeks apart

Consult your doctor for the best combination strategy for your goals.

Is Rejuran better than Botox or fillers?

They serve different purposes:

Rejuran: Improves overall skin quality, texture, and health. Works from within to regenerate skin. Best for fine lines, texture, elasticity.

Botox: Relaxes muscles to prevent dynamic wrinkles. Best for forehead lines, crow's feet, frown lines.

Fillers: Adds volume to restore lost fullness. Best for deep folds, cheek volume, lip enhancement.

Many patients use all three for comprehensive anti-aging results.

Can I get Rejuran if I'm allergic to salmon or seafood?

This is controversial. While Rejuran PN is highly purified and manufacturer states it's safe, some doctors recommend caution for those with severe seafood allergies. Discuss thoroughly with your doctor and consider patch testing.

When can I wear makeup after Rejuran?

• Minimum: 6-24 hours
• Recommended: 24-48 hours
• Full makeup: 2-3 days after injection marks have healed
• Use clean brushes and gentle products when you resume

Will my face look puffy or swollen?

Mild swelling is normal and typically resolves within 24 hours. Severe puffiness is rare. The embossing effect (bumps) may look concerning but isn't actually swelling—it's the product sitting in the dermis and will absorb quickly.

Can men get Rejuran?

Absolutely. Rejuran is suitable for all genders. Many male patients choose Rejuran for its subtle, natural-looking improvements without the obvious "done" look.

What's the best age to start Rejuran?

• Preventative: Late 20s to early 30s for those starting to see early signs of aging
• Corrective: 30s-50s for addressing established fine lines and elasticity loss
• Maintenance: Any age for maintaining skin health

There's no "too young" or "too old"—it depends on your skin condition and goals.

Top Clinics for Rejuran in Seoul

When choosing a clinic for Rejuran treatment in Korea, consider reputation, English-speaking staff, genuine products, and patient reviews. Here are top-rated options:

Gangnam Area

1. Nain Clinic (나인피부과)

• Location: Gangnam Station area, 463 Gangnam-daero, Seocho-gu
• Specialties: Skin boosters, comprehensive anti-aging treatments
• Languages: Korean, English
• Price Range: Rejuran Healer ₩108,900-220,000 (promotional rates)
• Why choose: Competitive pricing, experienced with international patients, modern facilities
• Booking: Available through Gangnam Unni app or direct contact

2. ID Skin Clinic (아이디피부과)

• Location: Sinsa Station, Gangnam
• Specialties: Over 20 types of skin boosters including all Rejuran variants
• Languages: Korean, English
• Why choose: Authentic products with strict expiration date management, specialized in injection treatments
• Notable: Strong focus on product authenticity and safety

3. Cha & Park Skin Clinic (차앤박피부과)

• Location: Multiple locations in Gangnam
• Specialties: Comprehensive dermatology, multiple skin booster options
• Languages: Korean, English
• Why choose: Variety of treatment options, experienced dermatologists, good for combining treatments

4. Mikey Clinic (미케이의원)

• Location: Gangnam Station area
• Specialties: Botox, fillers, and skin boosters
• Languages: Korean, English
• Why choose: Focused on injectable treatments, experienced practitioners

Other Seoul Areas

5. Apple Skin Clinic (애플피부과)

• Location: THE LOUNGE A
• Specialties: Medical dermatology and aesthetic treatments
• Languages: Korean, English (check in advance)

How to Book

Recommended booking platforms:

1. Gangnam Unni (강남언니) - Most popular Korean platform, 16,280+ clinic listings with real reviews
2. Modoodoc (모두닥) - 525,000+ reviews, price comparison features
3. MyDoctor (마이닥터) - Compare 134+ Gangnam clinics
4. Direct contact: Email or WhatsApp (many clinics have international patient coordinators)

Booking Tips

• Book in advance: Popular clinics fill up quickly, especially during peak tourist seasons
• Ask about packages: Multi-session packages offer significant savings
• Verify products: Ensure clinic uses authentic Rejuran products (check packaging)
• Read recent reviews: Check Gangnam Unni or Modoodoc for current patient experiences
• Confirm English support: Ensure clinic has English-speaking staff if needed

Final Thoughts: Is Rejuran Worth It?

Rejuran represents a different approach to skin rejuvenation—one that works with your body's natural healing processes rather than against them. Here's why it's worth considering:

Pros:

• Natural, biological approach to anti-aging
• Improves overall skin quality, not just symptoms
• Minimal downtime
• Cumulative, long-lasting results
• Safe with minimal side effects
• Significantly cheaper in Korea than elsewhere
• Complements other treatments well

Cons:

• Requires multiple sessions for best results
• Not instant—takes weeks to see full effects
• Moderate pain during treatment (Healer version)
• Temporary embossing and swelling
• Requires good aftercare compliance

Best candidates:

• Those seeking natural skin improvement
• Fine lines and early signs of aging
• Poor skin texture or elasticity
• Willing to invest in a series of treatments
• Realistic expectations about gradual results

If you're visiting Korea and considering cosmetic treatments, Rejuran offers excellent value and access to experienced practitioners. The cost savings alone make it worthwhile, but combined with Korea's advanced aesthetic medicine expertise, it's an opportunity to invest in your skin at a fraction of Western prices.

Medical Disclaimer

Important: This article is for informational purposes only and does not constitute medical advice. Rejuran treatment should only be performed by licensed medical professionals.

Before treatment:

• Consult with a qualified dermatologist or aesthetic doctor
• Disclose full medical history, allergies, and current medications
• Discuss realistic expectations and potential risks
• Ensure clinic uses authentic, properly stored products

Individual results vary based on age, skin condition, lifestyle, and treatment protocol. The prices and information provided are based on 2025 data and may change.

Serious side effects are rare but possible. Seek immediate medical attention if you experience signs of infection, severe allergic reaction, or complications.

Always prioritize safety and authenticity over price when choosing a clinic and provider.

Have you tried Rejuran treatment in Korea? We'd love to hear about your experience. Share your story to help other international visitors make informed decisions about their skincare journey in Seoul.

Sources

Information for this guide was compiled from current Korean medical and aesthetic sources:

• 리쥬란 가격정보 (2025) | 모두닥
• 리쥬란힐러 효과와 가격 | 강남언니
• 리쥬란힐러 vs 리쥬란HB 비교 | 강남언니
• 리쥬란 힐러 · 아이 · HB · S 차이 총정리 | Skinab
• 리쥬란 힐러 과정/효과/부작용 (2025) | 모두닥
• 리쥬란 시술 후 일상생활 가이드 | 마인성형외과
• 리쥬란힐러 시술 후 주의사항 | 제너리스
• 강남역 피부과 병원 비교 (2025) | 마이닥터