Rejuran Healer in Korea: Complete Guide to Salmon DNA Skin Booster 2025

If you've been following K-beauty trends, you've likely heard about Rejuran Healer (리쥬란 힐러)—one of Korea's most popular "skin booster" treatments that uses salmon DNA to regenerate skin from within. This innovative treatment has taken the Korean beauty industry by storm, with dermatology clinics across Seoul offering it as a foundational anti-aging and skin quality treatment.

Unlike fillers that add volume or Botox that relaxes muscles, Rejuran Healer works at the cellular level to stimulate your skin's natural healing and regeneration processes. Using PDRN (Polydeoxyribonucleotide)—a substance extracted from salmon DNA—this treatment promises improved skin texture, reduced wrinkles, enhanced elasticity, and overall skin rejuvenation.

This comprehensive guide covers everything international visitors need to know about Rejuran Healer in Korea, including the science behind PDRN, realistic pricing, what results to expect, potential side effects, and how it compares to other skin booster treatments.

What is Rejuran Healer?

Rejuran Healer is an injectable skin booster treatment that delivers PDRN (Polydeoxyribonucleotide) directly into the dermal layer of the skin. PDRN is a biological substance derived from salmon or trout DNA that has been fragmented and purified for medical use.

The Science Behind PDRN

What is PDRN?

PDRN is a mixture of DNA fragments extracted from salmon sperm. When purified and processed, these DNA fragments are structurally similar to human DNA, making them highly compatible with human tissue.

How does it work?

When injected into the skin, PDRN:

1. Stimulates cell regeneration: Activates dormant skin cells and promotes proliferation of healthy new cells

2. Enhances tissue repair: Triggers the release of cytokines and growth factors that accelerate healing

3. Boosts collagen production: Stimulates fibroblasts (collagen-producing cells) to generate new collagen

4. Improves microcirculation: Enhances blood flow to the skin, delivering more oxygen and nutrients

5. Reduces inflammation: Has anti-inflammatory properties that calm irritated skin

6. Provides antioxidant effects: Protects against free radical damage

PN vs. PDRN: Understanding the Difference

PN (Polynucleotide):

• Larger molecular structure
• Used in injectable treatments like Rejuran
• Penetrates to dermal layer
• Targets wrinkles, scars, and deep skin regeneration

PDRN (Polydeoxyribonucleotide):

• Smaller molecular structure
• Used in topical cosmetic products (serums, creams)
• Works on epidermis (skin surface)
• Focuses on skin barrier repair and anti-inflammation

Important: Rejuran injections actually use PN, but the treatment is often marketed under the PDRN umbrella term since both are salmon-derived nucleotides.

What Can Rejuran Healer Treat?

Rejuran Healer is particularly effective for:

✅ Fine lines and wrinkles: Softening superficial wrinkles through collagen stimulation ✅ Enlarged pores: Improving skin texture and minimizing pore appearance ✅ Skin elasticity loss: Restoring firmness and bounce to aging skin ✅ Dull, tired skin: Brightening overall complexion ✅ Acne scarring: Improving atrophic scars and skin texture irregularities ✅ Uneven skin tone: Reducing pigmentation and redness ✅ Dehydrated skin: Improving moisture retention ✅ Overall skin quality: Creating healthier, more resilient skin

Ideal Candidates

Best suited for:

• Ages 25-50 seeking preventive anti-aging care
• Those with early signs of aging (fine lines, loss of elasticity)
• People with textural concerns (large pores, rough skin)
• Individuals with acne scars or skin damage
• Those wanting comprehensive skin quality improvement
• People seeking natural-looking rejuvenation

Not ideal for:

• Those seeking immediate, dramatic results
• People with severe skin sagging (better suited to HIFU or surgery)
• Individuals with seafood/fish allergies (major contraindication)
• Those expecting volume addition (use fillers instead)

Expected Results and Timeline

Understanding the progressive nature of Rejuran results is crucial:

Patient Satisfaction Data

According to data from Korean dermatology clinics treating 2,121 Rejuran patients:

• 59% saw effects immediately after treatment: Initial plumpness and glow
• 36% noticed results within one week: Early regeneration signs
• 5% saw results within one month: Slower responders

Results Timeline

Immediate (Days 1-3):

• Skin appears plumper due to product volume and hydration
• Slight glow from improved circulation
• Initial healing response begins

Early Phase (Weeks 1-2):

• Subtle improvements in skin texture
• Enhanced radiance
• Reduced appearance of fine lines

Progressive Phase (Weeks 2-6):

• Noticeable improvement in skin quality
• Better elasticity and firmness
• Pore refinement becomes visible
• Reduced redness and more even tone

Peak Results (Weeks 6-12):

• Maximum collagen production
• Significant improvement in wrinkles and texture
• Enhanced overall skin health
• Cumulative effects from multiple sessions

Duration of Results

• Single treatment: 3-6 months
• Multiple treatments: Cumulative, longer-lasting effects
• With maintenance: Can sustain results indefinitely

Important: Rejuran is not a one-time fix. Optimal results require a series of treatments (typically 3-4 sessions) followed by periodic maintenance.

Rejuran Healer Prices in Korea (2025)

Based on current market data from Seoul clinics:

Overall Pricing

Prices as of November 2025. Exchange rate: ₩1,300 = $1 USD.

Pricing by Volume and Area

Promotional Pricing

Many clinics offer introductory rates:

• First-time visitors: ₩89,000-₩108,900 ($68-$84) for 2cc
• Package deals: 3-4 sessions at 20-30% discount
• Event pricing: Seasonal promotions can bring 2cc under ₩100,000 ($77)

Price Variables

Clinic location:

• Gangnam/Apgujeong premium: 30-50% higher
• Mid-range Seoul: Standard market rates
• Neighborhood clinics: 15-25% lower

Product version:

• Standard Rejuran Healer: Base pricing
• Rejuran HB Plus (with HA + lidocaine): 20-30% premium
• Rejuran I (for eyes): Similar to standard
• Rejuran S (for scars): May cost more

Practitioner:

• Experienced dermatologist: Higher rates
• Less experienced doctors: Lower rates
• Celebrity clinics: Premium pricing

Package Recommendations

Initial treatment series (most cost-effective):

• 3-4 sessions, 2-3 weeks apart
• Typical package: ₩600,000-₩1,200,000 ($462-$923)
• Per-session cost: ₩150,000-₩300,000 ($115-$231)

Types of Rejuran Products

The Rejuran brand offers several formulations for different purposes:

1. Rejuran Healer (Standard)

• Most common: The original and most widely used
• Target: Overall skin quality, anti-aging
• Volume: Usually 2cc per session
• Best for: General skin rejuvenation

2. Rejuran HB Plus

• Added ingredients: Hyaluronic acid (HA) + Lidocaine
• Benefits:
  • More hydration from HA
  • Less pain from lidocaine anesthetic
  • Combined regeneration + hydration effects
• Price: 20-30% more than standard Rejuran
• Best for: Those seeking enhanced hydration or pain-sensitive individuals

3. Rejuran I (Eye)

• Specialized for: Delicate eye area
• Target: Eye wrinkles, under-eye hollows, dark circles
• Formulation: Adapted for thin eye skin
• Best for: Periorbital aging concerns

4. Rejuran S (Scar)

• Specialized for: Acne scars and deep wrinkles
• Higher concentration: More potent PN formulation
• Target: Textural irregularities, atrophic scars
• Best for: Significant scarring or deep wrinkles

The Rejuran Treatment Procedure

Consultation (10-20 minutes)

Your dermatologist will:

• Assess your skin concerns and quality
• Check for contraindications (fish allergies!)
• Discuss realistic expectations
• Determine appropriate product and volume
• Take before photos

Pre-Treatment Preparation (10-15 minutes)

1. Allergy check: Some clinics perform a small patch test
2. Cleansing: Thorough facial cleansing
3. Numbing cream: Applied and left on for 15-20 minutes (crucial for comfort)
4. Marking (optional): Treatment zones outlined

Treatment Process (15-30 minutes)

Injection technique:

Rejuran is administered using either:

1. Needle injection: Multiple small injections across the face in a grid pattern

   • More controlled placement
   • Traditional method
   • Can be more uncomfortable

2. Injector gun: Automated micro-injection device

   • Faster, more uniform distribution
   • Less painful for some patients
   • Increasingly popular method

The "Embossing" Effect:

Immediately after injection, small raised bumps appear on the skin where the product was deposited. This is called "embossing" (엠보싱) and is completely normal.

• Bumps are most prominent immediately after treatment
• Usually subside within 1-3 hours
• Can take up to 24 hours to fully flatten
• More visible with 2cc+ volumes

Pain Level

On a scale of 1-10, patients typically rate Rejuran at 3-5:

• With numbing cream: Generally tolerable, feels like tiny pinpricks
• Without numbing: Can be quite uncomfortable
• HB Plus version: Less painful due to lidocaine

Pain is significantly lower than treatments like:

• Skin botox (micro-botox)
• Profhilo
• Some other skin boosters

Post-Treatment (5 minutes)

• Gentle cleansing to remove any product on skin surface
• Cooling or soothing mask may be applied
• Post-care instructions provided
• Can leave immediately

Post-Treatment Care and Downtime

Immediate After-Effects

The "bumpy" phase:

• Embossing (raised bumps) at injection sites: Normal, resolves within hours to 1 day
• Mild redness: Usually fades within hours
• Slight swelling: Particularly if treating larger areas
• Tenderness: Skin may feel sensitive to touch

Downtime

Actual downtime: Minimal

• Social downtime: 1-2 days (due to visible embossing)
• Work: Most return same day or next day
• Makeup: Can apply after 6-24 hours (varies by clinic recommendation)
• Exercise: Resume after 24-48 hours

First 24-48 Hours

✅ DO:

• Keep face clean with gentle cleanser
• Use mild, hydrating skincare
• Apply ice packs if swelling occurs
• Stay well-hydrated
• Sleep with head slightly elevated

❌ AVOID:

• Touching, rubbing, or massaging treated areas
• Makeup (first 6-24 hours)
• Hot environments (sauna, hot yoga, steam rooms)
• Strenuous exercise
• Alcohol consumption
• Blood thinners if possible

First Week

✅ DO:

• Resume normal gentle skincare after 48 hours
• Use SPF 30+ sunscreen daily
• Keep skin well-moisturized
• Be patient—results take time

❌ AVOID:

• Facial treatments (facials, peels, microneedling)
• Other injectable treatments
• Harsh exfoliants or active ingredients (retinoids, strong acids)
• Prolonged sun exposure

Optimizing Results

Support skin regeneration:

• Maintain healthy diet rich in protein and vitamins
• Stay hydrated (2+ liters water daily)
• Get adequate sleep (7-9 hours)
• Avoid smoking (impairs healing and collagen production)
• Manage stress
• Use quality skincare with antioxidants

Side Effects and Risks

Rejuran is generally considered safe, but side effects can occur:

Common (Usually Mild)

• Embossing: Temporary raised bumps (expected, not a complication)
• Redness: Usually resolves within hours to 1 day
• Swelling: Mild puffiness, especially in delicate areas
• Bruising: Small bruises at injection points (uncommon but possible)
• Tenderness: Sensitivity at injection sites for 1-3 days

Uncommon

• Prolonged swelling: Lasting more than 3 days
• Itching: Mild itchiness at injection sites
• Temporary skin dryness: Usually resolves quickly
• Asymmetry: Uneven product distribution

Rare but Important

⚠️ Allergic reactions: Critical concern for those with fish/seafood allergies

Symptoms:

• Hives or rash
• Itching beyond injection sites
• Facial swelling
• Difficulty breathing (seek immediate medical attention)

Prevention:

• Disclose all seafood/fish allergies during consultation
• Some clinics perform patch tests
• Start with smaller volumes if concerned

⚠️ Infection: Very rare with proper sterile technique

⚠️ Granulomas: Foreign body reaction (extremely rare)

⚠️ Vascular occlusion: Exceptionally rare (more common with fillers)

Managing Side Effects

For normal post-treatment effects:

• Apply ice packs for swelling
• Take oral antihistamines if mild itching occurs
• Use gentle skincare
• Allow time for embossing to resolve

When to contact your provider:

• Severe swelling that worsens after 24 hours
• Signs of infection (increasing redness, warmth, pus)
• Severe or spreading rash
• Any signs of allergic reaction
• Unusual or concerning symptoms

Who Should Avoid Rejuran?

Absolute contraindications: ❌ Fish or seafood allergies: Most critical contraindication ❌ Pregnant or breastfeeding ❌ Active skin infections in treatment area ❌ Active herpes outbreak ❌ Autoimmune diseases (relative contraindication—consult doctor) ❌ Cancer or history of skin cancer in treatment area ❌ Keloid scarring tendency

Relative contraindications (discuss with doctor): ⚠️ Blood clotting disorders ⚠️ Taking blood thinners (increased bruising risk) ⚠️ Recent facial procedures (wait appropriate period) ⚠️ Very sensitive skin ⚠️ Unrealistic expectations

Recommended Treatment Schedule

Initial Series

Standard protocol:

• Session 1: Baseline treatment
• 2-3 weeks later: Session 2
• 2-3 weeks later: Session 3
• Optional Session 4: 2-3 weeks after Session 3

Why multiple sessions? Results are cumulative. Each treatment builds on the previous one, stimulating progressively more collagen production and skin regeneration.

Maintenance Phase

After completing initial series:

Option 1: Regular maintenance

• Every 3-4 months
• Sustains collagen production
• Prevents regression

Option 2: As-needed maintenance

• Every 6-12 months
• When you notice effects diminishing
• More budget-friendly but less consistent results

Option 3: Intensive maintenance

• Every 1-2 months
• For aggressive anti-aging
• Higher cost but maximum results

Combining with Other Treatments

Rejuran works synergistically with many treatments:

✅ Can combine in single session:

• Botox (wait 1-2 weeks between for best results)
• Laser toning (non-ablative)
• LED light therapy
• Gentle chemical peels

✅ Schedule separately (2-4 weeks apart):

• Dermal fillers
• Skin botox/micro-botox
• Ablative laser treatments
• Microneedling
• HIFU (Shurink, Ulthera)

✅ Complementary skincare:

• PDRN serums (topical)
• Vitamin C
• Retinoids (after healing period)
• Hydrating products

Rejuran vs. Other Skin Boosters

How does Rejuran compare to other popular skin booster treatments?

Rejuran vs. Profhilo

Rejuran vs. Glass Skin Injection (물광주사)

Rejuran vs. Sculptra

Which Should You Choose?

Choose Rejuran if:

• Primary concern is skin quality and texture
• You have acne scars or rough skin
• You want biological regeneration rather than just hydration
• Budget is moderate
• You can commit to multiple sessions

Choose Profhilo if:

• Deep hydration and skin laxity are main concerns
• You want bio-remodeling effects
• Pain tolerance is good
• Budget allows for premium treatments

Choose Glass Skin Injection if:

• You want immediate glow
• Budget is limited
• You have an event coming up
• Hydration is the priority

Finding the Right Clinic in Seoul

Top Neighborhoods for Rejuran

Gangnam (강남)

• Highest concentration of experienced practitioners
• Latest Rejuran versions available
• English support widely available
• Price: Premium ($150-$250 for 2cc)

Apgujeong (압구정)

• Celebrity dermatologists
• Cutting-edge techniques
• Luxury clinic experience
• Price: Premium ($140-$230 for 2cc)

Myeongdong (명동)

• Tourist-friendly
• Competitive pricing
• Convenient location
• Price: Mid-range ($115-$180 for 2cc)

Hongdae/Sinchon (홍대/신촌)

• Budget-friendly options
• Good quality at lower prices
• Less English support
• Price: Budget ($80-$140 for 2cc)

Verifying Authentic Rejuran

Rejuran counterfeits exist. Protect yourself:

✅ Ask to see the product box before treatment ✅ Check for hologram stickers and Korean packaging ✅ Verify the expiration date ✅ Look for official Rejuran branding ✅ Choose reputable clinics with established reputations ✅ Be wary of suspiciously low prices

Essential Questions to Ask

1. "Which Rejuran product will you use?" (Healer, HB Plus, I, or S?)
2. "How much volume (cc) do you recommend for my concerns?"
3. "Can I see the sealed Rejuran product before treatment?"
4. "What numbing options are available?"
5. "How many Rejuran treatments do you perform per week?"
6. "What is your protocol if I have an allergic reaction?"
7. "When should I schedule follow-up sessions?"

Real Patient Experiences

What Patients Love

✔ "Skin texture improved dramatically after 3 sessions" ✔ "Fine lines around my eyes softened noticeably" ✔ "My acne scars look so much better" ✔ "Skin feels bouncier and more resilient" ✔ "Natural results—I just look healthier" ✔ "Less painful than expected with numbing cream" ✔ "The embossing went away within a few hours"

Common Concerns

✘ "Results took longer than I expected" ✘ "Pretty uncomfortable during injection despite numbing" ✘ "Had bumps on my face for a whole day" ✘ "Expensive to maintain with regular sessions" ✘ "Didn't see dramatic wrinkle reduction I hoped for" ✘ "Need to keep getting it—not a permanent fix"

Managing Expectations

Best results for:

• Those committed to a full treatment series (3-4 sessions)
• People with realistic expectations (improvement, not transformation)
• Patients seeking preventive care or early anti-aging
• Those with textural concerns, scars, or dull skin
• Individuals willing to maintain with periodic treatments

Disappointing results for:

• Those expecting immediate, dramatic changes
• People seeking only wrinkle elimination
• Single-session patients without follow-up
• Those with severe skin sagging (need HIFU or surgery instead)
• Patients not maintaining with proper skincare

FAQ

Q: Does Rejuran hurt? A: With numbing cream, most rate it 3-5 out of 10—tolerable but slightly uncomfortable. The HB Plus version with lidocaine is less painful.

Q: How long until I see results? A: 59% see some immediate effects, but true regeneration results develop over 2-6 weeks. Peak results occur after completing 3-4 sessions.

Q: How often should I get Rejuran? A: Initial series: 3-4 treatments, 2-3 weeks apart. Maintenance: Every 3-6 months depending on your goals and budget.

Q: Can I get Rejuran if I have seafood allergies? A: No. This is a critical contraindication. Rejuran is derived from salmon DNA and can cause severe allergic reactions in those allergic to fish.

Q: What are the bumps on my face after treatment? A: That's embossing—completely normal. The product creates temporary raised bumps that flatten within hours to 1 day.

Q: Is Rejuran better than Profhilo? A: Different purposes. Rejuran focuses on regeneration and texture; Profhilo on hydration and bio-remodeling. Both are excellent—choice depends on your primary concerns.

Q: Can I combine Rejuran with Botox or fillers? A: Yes, but space treatments 1-2 weeks apart for best results. Many patients do Rejuran for skin quality and Botox/fillers for specific wrinkles or volume.

Q: How long do Rejuran results last? A: 3-6 months per treatment, but effects are cumulative. Regular treatments create progressively better skin quality.

Q: Is there any downtime? A: Minimal functional downtime (can work same/next day), but embossing may make you self-conscious for 1-2 days socially.

Q: Can Rejuran help with acne scars? A: Yes, particularly the Rejuran S (scar) formulation. It won't eliminate deep scars but can significantly improve texture and shallow atrophic scarring.

Conclusion

Rejuran Healer has earned its reputation as one of Korea's foundational skin quality treatments for good reason. Using scientifically-backed PDRN (salmon DNA) technology to stimulate genuine cellular regeneration and collagen production, it offers comprehensive skin improvement that goes beyond superficial fixes.

Key takeaways:

• Science-based: PDRN has legitimate regenerative properties
• Affordable: Average $127 per session in Korea (much cheaper than Western countries)
• Effective: 59% see immediate effects; progressive results over weeks
• Safe: Generally well-tolerated with minimal side effects (if no fish allergies)
• Cumulative: Best results require 3-4 sessions + maintenance
• Natural-looking: Improves skin quality without dramatic changes

Best suited for:

• Ages 25-50 seeking preventive or early anti-aging care
• Those with textural concerns (pores, roughness, scars)
• People wanting biological skin improvement
• Individuals willing to commit to a treatment series
• Those seeking natural-looking rejuvenation

Critical considerations:

• Fish allergies are absolute contraindication—do not risk it
• Results require patience (weeks, not days)
• Maintenance treatments needed for sustained results
• Not a replacement for fillers (no volume addition) or HIFU (no significant lifting)
• Verify authentic Rejuran product to avoid counterfeits

Seoul offers some of the world's most experienced Rejuran practitioners at prices significantly lower than Western markets. With proper clinic selection, realistic expectations, and commitment to a treatment series, Rejuran Healer can deliver meaningful, lasting improvements in skin quality, texture, and overall health.

Ready to regenerate your skin from within? Consult a board-certified dermatologist in Seoul to determine if Rejuran Healer is right for your skin concerns and goals. Remember to disclose any seafood allergies and ask to verify authentic products before treatment.

⚠️ Medical Disclaimer: This article provides educational information about Rejuran Healer treatments. It is not medical advice, diagnosis, or treatment recommendation. Individual results vary significantly based on age, skin condition, treatment protocol, product authenticity, practitioner skill, and many other factors.

CRITICAL WARNING: Rejuran Healer contains salmon-derived DNA and is absolutely contraindicated for anyone with fish or seafood allergies. Allergic reactions can range from mild rash to severe anaphylaxis. If you have any fish allergies, do NOT undergo this treatment.

Rejuran treatments carry risks including allergic reactions, infection, bruising, swelling, asymmetry, and unsatisfactory results. While generally safe when performed by qualified professionals using authentic products, complications can occur.

Always consult with a qualified, board-certified dermatologist before undergoing any injectable treatment. Disclose your complete medical history, all allergies, medications, and previous procedures. Discuss realistic expectations, all potential risks and benefits, and alternative treatments.

Verify product authenticity: Counterfeit Rejuran products exist in the market. Ask to see sealed, authenticated products before treatment. Choose only reputable, licensed clinics with established track records.

Information about prices, protocols, products, and techniques is current as of November 2025 but may change. Verify all details directly with clinics before booking.

If you experience signs of allergic reaction (hives, swelling, difficulty breathing) or severe complications after Rejuran treatment, seek immediate medical attention.

Last Updated: November 11, 2025 Reading Time: 22 minutes