Polynucleotide (PN) Skin Treatment in Korea: Complete Guide 2025
Polynucleotide (PN) therapy has revolutionized Korean skin rejuvenation. Known through brands like Rejuran, this salmon-derived treatment offers deep skin healing and regeneration unlike any other.
What is Polynucleotide (PN)?
Polynucleotide is a biopolymer derived from salmon DNA that:
- Stimulates tissue regeneration
- Improves skin elasticity
- Enhances hydration
- Repairs damaged skin
- Reduces inflammation
PN works at the cellular level to fundamentally improve skin quality.
PN vs PDRN: Understanding the Difference
| Feature | PN | PDRN |
|---|---|---|
| Molecular weight | Higher (larger) | Lower (smaller) |
| Primary action | Structure + regeneration | Healing + anti-inflammation |
| Best for | Overall rejuvenation | Wound healing, repair |
| Popular brands | Rejuran | Various medical-grade |
| Texture improvement | Excellent | Good |
Both are derived from salmon DNA but have different molecular sizes and effects.
PN Prices in Korea (2025)
| Treatment | Price (KRW) | Price (USD) |
|---|---|---|
| Rejuran Healer | ₩200,000-350,000 | $155-270 |
| Rejuran S (Scar) | ₩200,000-400,000 | $155-310 |
| Rejuran I (Eye) | ₩150,000-300,000 | $115-230 |
| Rejuran HB | ₩200,000-350,000 | $155-270 |
| Package (3 sessions) | ₩500,000-900,000 | $385-690 |
Prices as of January 2025.
Korea vs. International
| Location | Per Session |
|---|---|
| Seoul | $155-310 |
| Singapore | $400-700 |
| Savings | 55-65% |
Types of PN Treatments
Rejuran Healer (Original)
- Standard PN formulation
- Overall skin rejuvenation
- Most popular option
Rejuran S (Scar)
- Higher concentration
- For acne scars
- Pitted skin treatment
Rejuran I (Eye)
- Lower viscosity
- Delicate eye area
- Dark circles, fine lines
Rejuran HB (Hydro Booster)
- Added hyaluronic acid
- Extra hydration
- Glow enhancement
Rejuran Tone-Up
- Brightening focus
- Pigmentation improvement
- Even skin tone
What PN Treats
Primary Benefits
| Concern | Effectiveness |
|---|---|
| Skin elasticity | Excellent |
| Fine lines | Very good |
| Skin texture | Excellent |
| Hydration | Very good |
| Acne scars | Good (S version) |
| Under-eye area | Good (I version) |
Ideal For
- Aging skin
- Loss of elasticity
- Rough texture
- Dehydrated skin
- Thin, fragile skin
- Post-acne concerns
The Treatment Process
Consultation
- Skin assessment
- Treatment selection
- Realistic expectations
During Treatment (30-45 minutes)
- Face cleansed
- Numbing cream applied (20-30 min)
- Multiple microinjections
- Soothing mask/care
Injection Technique
- Papule technique (small bumps)
- Multiple injection points
- Even distribution
Expected Results
| Timeframe | What to Expect |
|---|---|
| Day 1-3 | Small bumps visible |
| Week 1 | Bumps resolve, hydration improves |
| Week 2-4 | Texture improvement |
| Month 1-3 | Elasticity boost, glow |
| Month 3-6 | Optimal results |
Sessions Needed
| Goal | Sessions | Interval |
|---|---|---|
| Maintenance | 2-3 | Monthly |
| Improvement | 3-4 | 2-4 weeks |
| Intensive | 4-6 | 2-3 weeks |
Recovery
Day 1-3
- Small papules (bumps) visible
- Mild redness
- Avoid makeup 24 hours
Week 1
- Bumps flatten
- Normal activities resume
- Gentle skincare only
Long-term
- Sunscreen essential
- Results build over time
Side Effects
Expected
- Small bumps (1-3 days)
- Mild redness
- Temporary swelling
Rare
- Prolonged bumps
- Bruising
- Infection (very rare)
PN vs Other Treatments
| Treatment | Duration | Best For | Downtime |
|---|---|---|---|
| PN/Rejuran | 6-12 months | Elasticity, texture | 1-3 days |
| Skin Boosters | 4-6 months | Hydration | 1 day |
| PDRN | 3-6 months | Healing, repair | Minimal |
| PRP | 3-6 months | Regeneration | 1 day |
FAQ
Q: Does Rejuran hurt? A: Mild discomfort with numbing. Multiple small pricks.
Q: When do bumps go away? A: Usually 1-3 days, sometimes up to a week.
Q: How long do results last? A: 6-12 months with proper maintenance.
Q: Can I combine with other treatments? A: Yes, often paired with lasers or boosters.
Q: Is it safe for all skin types? A: Yes, PN is suitable for all skin types.
Conclusion
Polynucleotide therapy, particularly Rejuran, offers genuine skin regeneration that improves quality from within. Korea pioneered this treatment, and Seoul clinics offer the most competitive prices with extensive experience.
Want healthier, more resilient skin? Explore PN therapy at a Seoul dermatology clinic.
⚠️ Medical Disclaimer: This article provides general information. Always consult a qualified healthcare professional.
Last Updated: January 2025