PDRN Salmon DNA Injection in Korea: Complete Guide 2025
PDRN (Polydeoxyribonucleotide) therapy, commonly called "salmon DNA injection," has become one of Korea's most popular skin rejuvenation treatments. This regenerative therapy promotes healing, hydration, and overall skin health from within.
What is PDRN?
PDRN is a biological compound extracted from salmon or trout DNA (sperm/milt). It works at a cellular level to:
- Stimulate tissue repair: Activates adenosine A2A receptors
- Promote angiogenesis: New blood vessel formation
- Reduce inflammation: Anti-inflammatory effects
- Enhance cell proliferation: Stimulates fibroblast activity
- Boost collagen production: Improves skin structure
Originally used in wound healing and orthopedics, PDRN has been adapted for aesthetic medicine.
PDRN vs. Rejuran: What's the Difference?
Many confuse PDRN with Rejuran (PN - Polynucleotide):
| Feature | PDRN | PN (Rejuran) |
|---|---|---|
| Molecular size | Smaller | Larger |
| Source | Salmon DNA | Salmon DNA |
| Primary action | Regeneration, healing | Hydration, structure |
| Best for | Damaged skin, healing | Overall rejuvenation |
| Injection depth | Various | Dermal |
Both are derived from salmon DNA but have different molecular structures and uses.
PDRN Prices in Korea (2025)
| Treatment | Price (KRW) | Price (USD) |
|---|---|---|
| PDRN Injection (face) | ₩100,000-200,000 | $75-155 |
| PDRN + Skin Booster | ₩200,000-350,000 | $155-270 |
| PDRN IV Drip | ₩80,000-150,000 | $60-115 |
| PDRN Package (5 sessions) | ₩400,000-700,000 | $310-540 |
Prices as of January 2025.
Korea vs. International Pricing
| Location | Per Session |
|---|---|
| Seoul | $75-155 |
| Singapore | $200-400 |
| Savings | 50-60% |
Types of PDRN Treatments
1. PDRN Skin Injection
Method: Multiple microinjections into skin Target: Face, neck, hands, décolletage Best for: Overall skin rejuvenation
2. PDRN Mesotherapy
Method: Superficial skin injections Target: Specific problem areas Best for: Targeted treatment
3. PDRN IV Drip
Method: Intravenous administration Target: Systemic effects Best for: Overall healing support
4. PDRN + Combination
Method: Combined with other treatments Examples: PDRN + laser, PDRN + microneedling Best for: Enhanced results
What PDRN Treats
Primary Benefits
| Concern | Effectiveness |
|---|---|
| Skin regeneration | Excellent |
| Wound healing | Excellent |
| Post-procedure recovery | Excellent |
| Hydration | Good |
| Fine lines | Moderate |
| Skin texture | Good |
Best Applications
Post-Procedure Healing
- After laser treatments
- After microneedling
- After chemical peels
- Accelerates recovery
Skin Damage
- Acne scarring
- Sun damage
- Aged/damaged skin
- Sensitive skin
General Rejuvenation
- Dull complexion
- Dehydrated skin
- Early aging signs
- Skin strengthening
Expected Results
Timeline
| Timeframe | What to Expect |
|---|---|
| Week 1 | Improved hydration |
| Week 2-4 | Skin texture improving |
| Month 1-2 | Visible rejuvenation |
| Month 3+ | Continued improvement |
Realistic Expectations
| Goal | Achievability |
|---|---|
| Faster healing | High |
| Improved hydration | High |
| Skin regeneration | High |
| Wrinkle reduction | Moderate |
| Dramatic anti-aging | Low (subtle) |
The Treatment Process
Consultation
- Skin assessment
- Goal discussion
- Treatment plan creation
During Treatment (20-40 minutes)
For Skin Injection:
- Face cleansed
- Topical numbing (optional)
- Multiple small injections
- Soothing treatment applied
For IV Drip:
- IV line placed
- PDRN solution administered
- 15-30 minute drip
- IV removed
What It Feels Like
- Mild prickling (injections)
- Generally well-tolerated
- Less painful than many treatments
Recovery and Aftercare
Immediately After
- Mild redness (injection sites)
- Tiny bumps (resolve quickly)
- Resume normal activities
First 24-48 Hours
- Avoid makeup for 12-24 hours
- No intense exercise
- Stay hydrated
- Gentle skincare only
Long-Term
- Use sunscreen daily
- Maintain hydration
- Consider series of treatments
Side Effects
Common (Expected)
- Mild redness: Hours
- Small bumps: 24-48 hours
- Tenderness: Brief
Rare
- Allergic reaction (salmon allergy)
- Prolonged swelling
- Bruising
Who Should Avoid PDRN
❌ Salmon/fish allergy ❌ Active skin infections ❌ Pregnancy/breastfeeding (limited data)
PDRN Treatment Protocols
Recommended Sessions
| Goal | Sessions | Frequency |
|---|---|---|
| Post-procedure | 1-3 | Weekly |
| Skin regeneration | 3-5 | Bi-weekly |
| Maintenance | 1/month | Monthly |
| Intensive | 5-10 | Weekly |
Combination Protocols
PDRN + Laser
- Laser first
- PDRN immediately or next day
- Enhanced healing
PDRN + Microneedling
- Microneedling performed
- PDRN applied/injected
- Synergistic effects
PDRN + Skin Boosters
- Different mechanisms
- Complementary benefits
- Maximum rejuvenation
PDRN vs. Other Treatments
| Treatment | Primary Action | Duration | Best For |
|---|---|---|---|
| PDRN | Regeneration | Gradual | Healing, repair |
| Rejuran | Hydration/structure | 6-12 months | Overall rejuvenation |
| Skin Boosters | Hydration | 4-6 months | Moisture |
| PRP | Growth factors | Varies | Regeneration |
| Exosomes | Cell communication | Varies | Advanced repair |
Scientific Background
How PDRN Works
-
Adenosine A2A Receptor Activation
- Stimulates cell regeneration
- Anti-inflammatory effects
- Promotes healing
-
Salvage Pathway
- Provides nucleotides for DNA repair
- Supports cell proliferation
- Enhances tissue regeneration
-
Angiogenesis
- New blood vessel formation
- Better nutrient delivery
- Improved skin health
Finding Quality Treatment
What to Look For
✅ Quality PDRN products (Korean FDA approved) ✅ Experienced practitioner ✅ Proper storage of products ✅ Realistic expectations discussion
Questions to Ask
- What brand of PDRN do you use?
- Is it KFDA approved?
- How many sessions do you recommend?
- What results can I expect?
FAQ
Q: Is PDRN the same as Rejuran? A: Related but different. Both from salmon DNA, but different molecular structures and primary effects.
Q: Does it hurt? A: Mild discomfort with multiple small injections. Generally well-tolerated.
Q: How many sessions do I need? A: Typically 3-5 sessions, 2-4 weeks apart, for optimal results.
Q: Is it safe for sensitive skin? A: Yes, PDRN is known for being gentle and even beneficial for sensitive skin.
Q: Can I do PDRN if I'm allergic to fish? A: No, avoid PDRN if you have salmon or fish allergies.
Q: When will I see results? A: Hydration improves quickly. Full regenerative effects develop over 1-3 months.
Conclusion
PDRN salmon DNA injection offers genuine regenerative benefits for skin health and healing. Popular in Korea both as a standalone treatment and for post-procedure recovery, it's an excellent option for those seeking cellular-level skin improvement.
Looking to regenerate and heal your skin? Consult with a qualified Seoul clinic to explore PDRN therapy options.
⚠️ Medical Disclaimer: This article provides general information about PDRN treatments. It is not intended as medical advice. Always consult with a qualified healthcare professional before undergoing any medical treatment.
Last Updated: January 2025